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[Immunological study in sickle cell disease patients: importance of the complement system].

Authors: Sassi, F  Bardi, R  Neji, T  Ayed, K  Ben Dridi, MF 
Citation: Sassi F, etal., Tunis Med. 2003 Mar;81(3):195-9.
Pubmed: (View Article at PubMed) PMID:12793071

Ten Tunisian patients, with homozygote sickle cell disease and asplenia were studied to investigate and to determine possible immunological function defects. Obtained results directed us to an abnormality of the alternate complement pathway activation which is expressed by a decreased hemolytic activity, while the classic pathway is normal. Quantification of C3, C4, C5, C6, C7 and factor B by immunochemical assay were normal, whereas factor B functional activity was depressed to a mean level of about half of normal in eight patients, IgG was increased in one subject and IgA in two others. Numeration of Band T cells revealed slight decrease in proportion of CD3 and CD4 at one patient associated with an increase in B cells, but normal or increased absolute numbers of all cells population.

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RGD Object Information
RGD ID: 11041160
Created: 2016-03-23
Species: All species
Last Modified: 2016-03-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.