RGD Reference Report - [Immunological study in sickle cell disease patients: importance of the complement system]. - Rat Genome Database

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[Immunological study in sickle cell disease patients: importance of the complement system].

Authors: Sassi, F  Bardi, R  Neji, T  Ayed, K  Ben Dridi, MF 
Citation: Sassi F, etal., Tunis Med. 2003 Mar;81(3):195-9.
RGD ID: 11041160
Pubmed: PMID:12793071   (View Abstract at PubMed)

Ten Tunisian patients, with homozygote sickle cell disease and asplenia were studied to investigate and to determine possible immunological function defects. Obtained results directed us to an abnormality of the alternate complement pathway activation which is expressed by a decreased hemolytic activity, while the classic pathway is normal. Quantification of C3, C4, C5, C6, C7 and factor B by immunochemical assay were normal, whereas factor B functional activity was depressed to a mean level of about half of normal in eight patients, IgG was increased in one subject and IgA in two others. Numeration of Band T cells revealed slight decrease in proportion of CD3 and CD4 at one patient associated with an increase in B cells, but normal or increased absolute numbers of all cells population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CFBHumansickle cell anemia  IDA protein:decreased activityRGD 
CfbRatsickle cell anemia  ISOCFB (Homo sapiens)protein:decreased activityRGD 
CfbMousesickle cell anemia  ISOCFB (Homo sapiens)protein:decreased activityRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cfb  (complement factor B)

Genes (Mus musculus)
Cfb  (complement factor B)

Genes (Homo sapiens)
CFB  (complement factor B)


Additional Information