RGD Reference Report - FcgammaRIIa and FcgammaRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt. - Rat Genome Database

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FcgammaRIIa and FcgammaRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt.

Authors: Eyada, TK  Farawela, HM  Khorshied, MM  Shaheen, IA  Selim, NM  Khalifa, IA 
Citation: Eyada TK, etal., Blood Coagul Fibrinolysis. 2012 Jan;23(1):64-8. doi: 10.1097/MBC.0b013e32834ddf2f.
RGD ID: 11040989
Pubmed: PMID:22123287   (View Abstract at PubMed)
DOI: DOI:10.1097/MBC.0b013e32834ddf2f   (Journal Full-text)

Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. The current case-control study aimed at detecting the frequency of FcgammaRIIa-131H/R and FcgammaRIIIa-158F/V genes polymorphism in Egyptian children with ITP as genetic markers for ITP risk, and to clear out their possible role in choosing the treatment protocols of ITP. To achieve this aim, FcgammaRIIa genotyping was tested by PCR-restriction fragment length polymorphism (RFLP) technique, whereas FcgammaRIIIa genotyping was tested by nested PCR followed RFLP analysis. The current case-control study was conducted on 92 children with ITP; 12 acute and 80 chronic cases and 90 controls. The V allele and FcgammaRIIIa FV heterotype were significantly higher in ITP patients and conferred increased ITP risk [odds ratio (OR) = 1.96 and 2.55, respectively]. The frequency of FcgammaRIIa H allele was significantly higher among chronic ITP patients. In conclusion, FcgammaRIIIa gene polymorphism may contribute to susceptibility to ITP. Moreover, analysis of the FcgammaR polymorphisms in ITP patients could influence the effectiveness of medications and selection of the line of treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanautoimmune thrombocytopenic purpura susceptibilityIAGP DNA:SNP:cds:p.R131H (human)RGD 
FCGR3AHumanautoimmune thrombocytopenic purpura susceptibilityIAGP DNA:SNP:exon:p.F158V (rs396991) (human)RGD 
Fcgr2aRatautoimmune thrombocytopenic purpura susceptibilityISOFCGR2A (Homo sapiens)DNA:SNP:cds:p.R131H (human)RGD 
Fcgr3Mouseautoimmune thrombocytopenic purpura susceptibilityISOFCGR2A (Homo sapiens)DNA:SNP:cds:p.R131H (human)RGD 
Fcgr3aRatautoimmune thrombocytopenic purpura susceptibilityISOFCGR3A (Homo sapiens)DNA:SNP:exon:p.F158V (rs396991) (human)RGD 
Fcgr4Mouseautoimmune thrombocytopenic purpura susceptibilityISOFCGR3A (Homo sapiens)DNA:SNP:exon:p.F158V (rs396991) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)
Fcgr3a  (Fc gamma receptor 3A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)
Fcgr4  (Fc receptor, IgG, low affinity IV)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)
FCGR3A  (Fc gamma receptor IIIa)

Additional Information