RGD Reference Report - [Protective effects and anticoagulation effect of polysaccharides from the sea cucumber on acute incomplete cerebral ischemia in rats]. - Rat Genome Database

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[Protective effects and anticoagulation effect of polysaccharides from the sea cucumber on acute incomplete cerebral ischemia in rats].

Authors: Jiang, Xin  Xu, Jing  Su, Xiu-Rong  Li, Yan-Yan 
Citation: Jiang X, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):170-2.
RGD ID: 11040923
Pubmed: PMID:22737923   (View Abstract at PubMed)


OBJECTIVE: To investigate the protective effect and anticoagulation effect of polysaccharides from the sea cucumber (PSU) on acute incomplete cerebral ischemia (AICI).
METHODS: Adult SD rats were randomly divided into 5 group (n = 12): sham operation group, model group, low-dose (30 mg/(kg x d)), middle-dose (60 mg/(kg x d)) and high-dose (120 mg/(kg x d)) groups. The cerebral ischemia rat model was established by permanently ligating the common carotid arteries on both sides of rats. We observed the change of behavior disturbance, brain water content, the levels of serum C-reactive protein (CRP) as well as the effects on prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen(FIB).
RESULTS: Due to the use of polysaccharides, the behavioral disturbance was improved, brain water content and the levels of serum CRP were significantly decreased. Also PSU significantly prolonged APTT, TT and reduced the content of FIB (P < 0.05).
CONCLUSION: PSU has protective effect on acute incomplete cerebral ischemia injured rats and significant anticoagulation effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia treatmentISOFga (Rattus norvegicus)11040923; 11040923 RGD 
brain ischemia treatmentIDA 11040923 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fga  (fibrinogen alpha chain)

Genes (Mus musculus)
Fga  (fibrinogen alpha chain)

Genes (Homo sapiens)
FGA  (fibrinogen alpha chain)


Additional Information