RGD Reference Report - Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice. - Rat Genome Database

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Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice.

Authors: Huang, HS  Sun, DS  Lien, TS  Chang, HH 
Citation: Huang HS, etal., Blood. 2010 Dec 2;116(23):5002-9. doi: 10.1182/blood-2010-03-275123. Epub 2010 Aug 10.
RGD ID: 11040883
Pubmed: PMID:20699442   (View Abstract at PubMed)
DOI: DOI:10.1182/blood-2010-03-275123   (Journal Full-text)

Intravenous immunoglobulin (IVIg) is an effective treatment against immune thrombocytopenia (ITP). Previous studies suggested that IVIg exerts this ameliorative role through 2 different leukocyte subsets. Dendritic cells (DCs) modulate the immunosuppression in an adoptive cell transfer model, and phagocytes up-regulate their inhibitory IgG Fc receptors (FcgammaR)IIB expression and thereby ameliorate the inflammatory response and platelet clearance. However, whether or not regulatory mechanisms exist among DCs, phagocytes, and platelets is still largely unknown. In this study we present findings that IVIg-primed splenic CD11c(+) DCs (IVIg-DCs) primarily mediate their anti-inflammatory effects at the level of the platelet rather than the phagocyte. IVIg-DCs did not ameliorate ITP in Fcgr2b(-/-), Fcgr3(-/-), nor P-Selp(-/-) mice, implicating the potential involvement of these pathways in IVIg action. As platelets are a component of DC regulatory circuits, these findings may suggest an alternative perspective for the use of IVIg treatment.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanautoimmune thrombocytopenic purpura  ISOFcgr3 (Mus musculus) RGD 
Fcgr2aRatautoimmune thrombocytopenic purpura  ISOFcgr3 (Mus musculus) RGD 
Fcgr3Mouseautoimmune thrombocytopenic purpura  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information