RGD Reference Report - [The diagnostic of defects of inborn immunity under B-cell tumors of lymphatic system]. - Rat Genome Database

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[The diagnostic of defects of inborn immunity under B-cell tumors of lymphatic system].

Authors: Nazarova, EL  Shardakov, VI  Dem'ianova, VT  Zagoskina, TP  Zotina, EN 
Citation: Nazarova EL, etal., Klin Lab Diagn. 2014 Nov;59(11):39-42.
RGD ID: 11040778
Pubmed: PMID:25850245   (View Abstract at PubMed)

The genetic characteristics are key risk factors of development of many human neoplasms including B-cell tumors of lymphatic system. The relationship between polymorphic variants of genes FCGR2A (His 1 66Agr), CD14 (C-159T). IL1beta (T-31C), IL2 (7:330G) and 7LR2 (Arg753Ghn) and development of various forms of B-cell tumors of lymphatic system in 80 patients was investigated. The statistically significant differences of rates of particiular genotypes of single nucleotid polymorphisms of genes FCGR2A, CD14. IL1beta, IL2 and TLR2 in patients with indolent and aggressive types of course of non-Hodgkin lymphoma and also multiple myeloma. The results prove hypothesis that genetic variants of genes of inborn immune response effect the origin and character of course of different types of lymphoproliferative diseases. The markers can become additional prognostic characteristics of benign and aggressive course of tumors.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanmultiple myeloma disease_progressionIAGP  RGD 
Fcgr2aRatmultiple myeloma disease_progressionISOFCGR2A (Homo sapiens) RGD 
Fcgr3Mousemultiple myeloma disease_progressionISOFCGR2A (Homo sapiens) RGD 
FCGR2AHumannon-Hodgkin lymphoma disease_progressionIAGP  RGD 
Fcgr2aRatnon-Hodgkin lymphoma disease_progressionISOFCGR2A (Homo sapiens) RGD 
Fcgr3Mousenon-Hodgkin lymphoma disease_progressionISOFCGR2A (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Mus musculus)
Fcgr3  (Fc receptor, IgG, low affinity III)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information