RGD Reference Report - Thyrotropin-induced expression of a gene for a ribosomal protein related to the trk oncogene. - Rat Genome Database

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Thyrotropin-induced expression of a gene for a ribosomal protein related to the trk oncogene.

Authors: Chazenbalk, GD  Wadsworth, HL  Rapoport, B 
Citation: Chazenbalk GD, etal., Mol Cell Endocrinol. 1990 Jan 2;68(1):R25-30.
RGD ID: 11039447
Pubmed: PMID:2303158   (View Abstract at PubMed)

By differential screening of an FRTL5 rat thyroid cell cDNA library, we isolated a clone (G7) corresponding to an mRNA transcript whose steady-state level is increased by thyrotropin (TSH) stimulation by a non-transcriptional mechanism. The nucleotide sequence of the G7 cDNA (0.85 kb) revealed homology with two other genes. First, there was 89% homology with the cDNA for a protein whose amino-terminal end forms the amino terminus of the chimeric tyrosine kinase human oncogene, trk-2h. Second, TSH-responsive G7 is 95% homologous with the 'surf-3' gene within the mouse surfeit locus which codes for the mouse L7a ribosomal protein. These findings are of interest in view of the frequent occurrence in thyroid cancers of an oncogene (PTC) that consists of an unidentified amino terminus linked to a downstream tyrosine kinase moiety.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to Thyroid stimulating hormone  IEP 11039447 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rpl7a  (ribosomal protein L7A)


Additional Information