RGD Reference Report - Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo. - Rat Genome Database

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Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo.

Authors: Jin, H  Yang, X  Liu, K  Gu, Q  Xu, X 
Citation: Jin H, etal., FEBS Lett. 2011 Nov 4;585(21):3457-64. doi: 10.1016/j.febslet.2011.10.002. Epub 2011 Oct 10.
RGD ID: 11038716
Pubmed: PMID:22001200   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2011.10.002   (Journal Full-text)

Thrombomodulin (TM) is a single-transmembrane glycoprotein receptor for thrombin, which is best known as a cofactor for thrombin-mediated activation of anticoagulant protein C. C-type lectin-like domain (CTLD) of TM has distinct coagulation/fibrinolysis-independent anti-inflammatory properties. Here we found anti-inflammatory effects of a novel peptide (GC31) from CTLD of TM in endotoxin-induced uveitis, which was characterized by a reduction of leukocyte counts, protein concentration, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 levels in aqueous humor. Through in vitro experiments, we further found that GC31 suppressed TNF-alpha and interleukin (IL)-6 expressions in lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells and interrupted LPS-induced nuclear factor-kappaB (NF-kappaB) activation. These data indicate a beneficial role of peptide GC31 in preventing intraocular inflammatory response, especially uveitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Endotoxin-Induced Uveitis treatmentIDA 11038716 RGD 
Endotoxin-Induced Uveitis treatmentISOTHBD (Homo sapiens)11038716; 11038716 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Thbd  (thrombomodulin)

Genes (Mus musculus)
Thbd  (thrombomodulin)

Genes (Homo sapiens)
THBD  (thrombomodulin)


Additional Information