RGD Reference Report - Haem and drug-metabolizing enzymes in regenerating rat liver. - Rat Genome Database

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Haem and drug-metabolizing enzymes in regenerating rat liver.

Authors: Srivastava, RC  Dwivedi, RS  Kaur, G  Srivastava, R 
Citation: Srivastava RC, etal., Br J Exp Pathol. 1982 Feb;63(1):1-4.
RGD ID: 11035238
Pubmed: PMID:6895999   (View Abstract at PubMed)
PMCID: PMC2040734   (View Article at PubMed Central)

Various parameters of haem and drug metabolism were measured during the course of liver regeneration after two-thirds hepatectomy. Partial hepatectomy produced a significant depression in delta-ALA synthetase and delta-ALA dehydratase, and induction in haem oxygenase at an early stage of regeneration. The values returned to normal within 7-14 days. These changes were also accompanied by a marked decline in benzo(a)pyrene hydroxylase and aminopyrene demethylase. The level of glutathione and the activity of glutathione reductase also increased during the early stage of proliferation. The increased level of glutathione with concomitant decrease in drug-metabolizing enzymes and induction in haem oxygenase could be considered as a protective mechanism for the detoxication process, although a contribution from other biotransforming mechanisms cannot be excluded.

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Alas2  (5'-aminolevulinate synthase 2)

Additional Information