RGD Reference Report - SNRPE is involved in cell proliferation and progression of high-grade prostate cancer through the regulation of androgen receptor expression. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

SNRPE is involved in cell proliferation and progression of high-grade prostate cancer through the regulation of androgen receptor expression.

Authors: Anchi, T  Tamura, K  Furihata, M  Satake, H  Sakoda, H  Kawada, C  Kamei, M  Shimamoto, T  Fukuhara, H  Fukata, S  Ashida, S  Karashima, T  Yamasaki, I  Yasuda, M  Kamada, M  Inoue, K  Shuin, T 
Citation: Anchi T, etal., Oncol Lett. 2012 Feb;3(2):264-268. Epub 2011 Dec 1.
RGD ID: 10768830
Pubmed: PMID:22740892   (View Abstract at PubMed)
PMCID: PMC3362443   (View Article at PubMed Central)
DOI: DOI:10.3892/ol.2011.505   (Journal Full-text)

Clinically high-grade prostate cancers (PC) with high Gleason scores of 8-10 exhibit rapid growth and are more likely to spread beyond the prostate. These cancer types demonstrate a poor response to androgen deprivation therapy and eventually acquire a castration-resistant phenotype. To identify novel molecular cancer drug targets, we previously analyzed the gene expression profiles of high-grade PC using a cDNA microarray combined with laser microbeam microdissection and found a number of genes that are transactivated in high-grade PC. Among these genes, we report the identification of a novel molecular target, small nuclear ribonucleoprotein polypeptide E (SNRPE). Semi-quantitative RT-PCR confirmed that SNRPE is overexpressed in high-grade PC cells compared with normal prostatic epithelial cells. Knockdown of SNRPE expression by short interfering RNA (siRNA) resulted in the marked suppression of PC cell proliferation. By contrast, SNRPE overexpression promoted PC cell proliferation, indicating its oncogenic effects. Furthermore, we demonstrated that SNRPE regulates androgen receptor (AR) mRNA expression in PC cells. Knockdown of SNRPE expression by siRNA resulted in the marked suppression of AR and its downstream target genes at the mRNA level. We suggest that the regulation of AR expression by SNRPE is essential for cell proliferation and progression of high-grade PC and that it may be a novel molecular target for cancer drugs.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer severityIEP 10768830mRNA:increased expression:prostate gland (human)RGD 
prostate cancer severityISOSNRPE (Homo sapiens)10768830; 10768830mRNA:increased expression:prostate gland (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Snrpe  (small nuclear ribonucleoprotein polypeptide E)

Genes (Mus musculus)
Snrpe  (small nuclear ribonucleoprotein E)

Genes (Homo sapiens)
SNRPE  (small nuclear ribonucleoprotein polypeptide E)


Additional Information