RGD Reference Report - Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax. - Rat Genome Database

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Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax.

Authors: Chung, MC  Jorgensen, SC  Popova, TG  Bailey, CL  Popov, SG 
Citation: Chung MC, etal., FEMS Immunol Med Microbiol. 2008 Dec;54(3):309-18. doi: 10.1111/j.1574-695X.2008.00480.x.
RGD ID: 10450550
Pubmed: PMID:19049643   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1574-695X.2008.00480.x   (Journal Full-text)

Bacillus anthracis infection is associated with severe hemostatic disturbances but their roles and contribution to fatality remain incompletely characterized. We undertook analyses of circulating antithrombin levels during the course of infection using a comparison of lethal and nonlethal murine anthrax models. Plasma samples were obtained from DBA/2 mice challenged intraperitoneally with the spores of either toxigenic B. anthracis Sterne strain or nontoxigenic, avirulent delta Sterne strain. We found that plasma antithrombin levels were rapidly depleted in Sterne spore-challenged mice, concomitant with elevation of neutrophil elastase (NE) and massive syndecan shedding from the liver into circulation. The shed syndecan bound with antithrombin accelerated NE-mediated antithrombin proteolysis. The liver response to infection demonstrated strain-specific compensatory increases of antithrombin and syndecan gene transcription. Both bacterial strains induced changes in blood coagulation parameters consistent with the onset of disseminated intravascular coagulation. We propose that antithrombin depletion proceeding through activation of neutrophils and massive shedding of heparin-like syndecan from the liver into circulation contribute to anthrax coagulopathy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ELANEHumananthrax disease  ISOElane (Mus musculus)protein:increased expression:plasma:RGD 
ElaneRatanthrax disease  ISOElane (Mus musculus)protein:increased expression:plasma:RGD 
ElaneMouseanthrax disease  IEP protein:increased expression:plasma:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Elane  (elastase, neutrophil expressed)

Genes (Mus musculus)
Elane  (elastase, neutrophil expressed)

Genes (Homo sapiens)
ELANE  (elastase, neutrophil expressed)


Additional Information