RGD Reference Report - Expression and functional analysis of granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia. - Rat Genome Database

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Expression and functional analysis of granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia.

Authors: Sultana, TA  Harada, H  Ito, K  Tanaka, H  Kyo, T  Kimura, A 
Citation: Sultana TA, etal., Br J Haematol. 2003 Apr;121(1):63-75.
RGD ID: 10450504
Pubmed: PMID:12670333   (View Abstract at PubMed)

CD34++ cells from 45 patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia (MDS-AML) were observed by flow cytometry for the expression of granulocyte colony-stimulating factor receptor (G-CSFR). Ten patients had a significantly reduced expression of G-CSFR. Late stages of disease showed a higher proportion of either high or low G-CSFR expression than earlier stages. In MDS refractory anaemia (RA), G-CSFR was inversely related to CD33 expression. Most patients (9/10) with low G-CSFR expression had neutropenia of the peripheral blood. Neutropenia was less common in the normal group, but also occurred in the high expression group. No neutrophil response was observed following G-CSF administration to MDS-AML patients (6/6) with low G-CSFR expression. In the high expression group, patients (3/3) showed a response to G-CSF while, in the normal group (1/2), the response was minor. In the normal- or high-receptor-expressing groups, the receptors were functionally active in terms of apoptosis but not proliferation and clonogenic growth, although no clear correlation to receptor expression was observed. The G-CSFR signal transduction pathway in the normal and high group was not deficient of messenger RNA for either janus kinases (Jaks) or signal transducers and activators of transcription (Stats). These findings suggest that the lowered expression of G-CSFR may cause neutropenia in MDS and MDS-AML patients and, therefore, may partially explain the neutropenia in myelodysplastic patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CSF3RHumanmyelodysplastic syndrome  IEP Protein:decreased expression:CD34++ cell:RGD 
Csf3rRatmyelodysplastic syndrome  ISOCSF3R (Homo sapiens)Protein:decreased expression:CD34++ cell:RGD 
Csf3rMousemyelodysplastic syndrome  ISOCSF3R (Homo sapiens)Protein:decreased expression:CD34++ cell:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf3r  (colony stimulating factor 3 receptor)

Genes (Mus musculus)
Csf3r  (colony stimulating factor 3 receptor)

Genes (Homo sapiens)
CSF3R  (colony stimulating factor 3 receptor)


Additional Information