RGD Reference Report - GCSF-R expression in myelodysplastic and myeloproliferative disorders and blast dysmaturation in CML. - Rat Genome Database

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GCSF-R expression in myelodysplastic and myeloproliferative disorders and blast dysmaturation in CML.

Authors: Hanumanthu, VS  Pirruccello, SJ 
Citation: Hanumanthu VS and Pirruccello SJ, Am J Clin Pathol. 2013 Aug;140(2):155-64. doi: 10.1309/AJCPCLHZR5KUHUBM.
RGD ID: 10450501
Pubmed: PMID:23897249   (View Abstract at PubMed)
DOI: DOI:10.1309/AJCPCLHZR5KUHUBM   (Journal Full-text)

OBJECTIVES: To characterize granulocyte colony-stimulating factor receptor (CD114) expression in normal (n = 20), myelodysplastic (n = 34), and chronic myelogenous leukemia (CML; n = 5) bone marrow by flow cytometry. METHODS: Clinical bone marrow samples were analyzed using CD33/CD114/CD34/CD117/CD45. CD114 density (mean fluorescence intensity) and cellular distribution were evaluated on early blasts (CD33-), late blasts (CD33+), promyelocytes, and granulocytes. RESULTS: Normal CD114 acquisition occurred on early blasts, peaked on promyelocytes, and decreased on granulocytes. Forty percent of CD34+ blasts expressed CD114 and one-third were early blasts. In myelodysplastic syndromes, altered CD114 distribution was more informative than density changes. In CML, CD114 density was significantly decreased on early blasts and expression was essentially limited to late blasts. We observed a specific blast dysmaturation pattern in CML involving CD33, CD34, and CD114 that was 83% sensitive and 100% specific in initial diagnosis. CONCLUSIONS: CD114 provides useful additional detail in phenotypic assessment of hematopoietic precursor maturation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CSF3RHumanmyeloproliferative neoplasm  IEP  RGD 
Csf3rRatmyeloproliferative neoplasm  ISOCSF3R (Homo sapiens) RGD 
Csf3rMousemyeloproliferative neoplasm  ISOCSF3R (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf3r  (colony stimulating factor 3 receptor)

Genes (Mus musculus)
Csf3r  (colony stimulating factor 3 receptor)

Genes (Homo sapiens)
CSF3R  (colony stimulating factor 3 receptor)


Additional Information