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Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte band 3 protein.

Authors: Barker, RN  De Sa Oliveira, GG  Elson, CJ  Lydyard, PM 
Citation: Barker RN, etal., Eur J Immunol. 1993 Jul;23(7):1723-6.
Pubmed: (View Article at PubMed) PMID:8325343
DOI: Full-text: DOI:10.1002/eji.1830230750

NZB mice spontaneously develop autoimmune hemolytic anemia (AIHA). The red blood cell (RBC) autoantigen bound by pathogenic IgG autoantibodies, previously designated "X", was identified by immunoprecipitation. Autoantibody eluted from the RBC of AIHA-positive NZB mice precipitated a 105-kDa antigen that was identical in apparent molecular mass to Band 3, the RBC anion channel protein. Furthermore, the immunoblotted antigen also reacted specifically with BRIC 132, a monoclonal antibody against Band 3. The results, therefore, demonstrate that Band 3 bears autoantigenic epitopes that are important in the pathogenesis of AIHA in the NZB mouse.

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RGD Object Information
RGD ID: 10450476
Created: 2016-01-13
Species: All species
Last Modified: 2016-01-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.