RGD Reference Report - Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep. - Rat Genome Database

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Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep.

Authors: Kimura, M  Inoue, S 
Citation: Kimura M and Inoue S, Psychiatry Clin Neurosci. 2002 Jun;56(3):337-8.
RGD ID: 10449529
Pubmed: PMID:12047622   (View Abstract at PubMed)
DOI: DOI:10.1046/j.1440-1819.2002.00968.x   (Journal Full-text)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a crucial cytokine for establishing pregnancy. It has been demonstrated previously in rats that sleep increases during early pregnancy and that centrally administered GM-CSF promotes both rapid eye movement (REM) and non-REM sleep. Therefore, whether GM-CSF is involved in pregnancy-enhanced sleep was investigated using the anti-GM-CSF antibody. Female rats received an intracerebroventricular infusion of either anti-GM-CSF or control IgG (10 microg each) for four nights from the first day of pregnancy (PD1-PD4). Although sleep amounts on PD1 were not affected, anti-GM-CSF decreased non-REM and REM sleep significantly during PD2-PD4 compared with the control baseline of the IgG group. The results demonstrated that anti-GM-CSF treatment suppresses pregnancy-enhanced sleep, suggesting that GM-CSF contributes to sleep regulation during pregnancy.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of circadian sleep/wake cycle, sleep  IMP 10449529 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf2  (colony stimulating factor 2)

Additional Information