RGD Reference Report - Correlation between platelet-derived growth factor B chain and bone resorption in rat periapical lesions. - Rat Genome Database

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Correlation between platelet-derived growth factor B chain and bone resorption in rat periapical lesions.

Authors: Wang, L  Peng, B 
Citation: Wang L and Peng B, J Endod. 2007 Jun;33(6):709-11. Epub 2007 Apr 17.
RGD ID: 10449488
Pubmed: (View Article at PubMed) PMID:17509411
DOI: Full-text: DOI:10.1016/j.joen.2007.03.002

The purpose of this study was to examine the relationship between platelet-derived growth factor B chain (PDGF-B) and bone resorption in rat periapical lesions. Periapical lesions were induced in Sprague-Dawley rats by occlusal exposure of the pulp of their mandibular first molars. Animals were sacrificed randomly at 0, 7, 14, 21, and 28 days after the exposure, and frontal sections were prepared for immunohistochemistry and enzymehistochemistry. PDGF-B-positive cells and osteoclasts could be observed on day 7. From day 7 to day 14, the number of PDGF-B-positive cells and osteoclasts were ascending, and a significant correlation was found between them; from day 21 to day 28, more PDGF-B-positive cells and fewer osteoclasts could be observed, and the positive expression of PDGF-B was negatively correlated with osteoclasts. These findings showed that PDGF-B could be observed, which might be associated with the bone resorption of periapical lesions.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Pdgfb  (platelet derived growth factor subunit B)

Genes (Mus musculus)
Pdgfb  (platelet derived growth factor, B polypeptide)

Genes (Homo sapiens)
PDGFB  (platelet derived growth factor subunit B)


Additional Information