RGD Reference Report - Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix. - Rat Genome Database

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Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix.

Authors: Hollinger, JO  Onikepe, AO  MacKrell, J  Einhorn, T  Bradica, G  Lynch, S  Hart, CE 
Citation: Hollinger JO, etal., J Orthop Res. 2008 Jan;26(1):83-90.
RGD ID: 10449446
Pubmed: PMID:17676626   (View Abstract at PubMed)
DOI: DOI:10.1002/jor.20453   (Journal Full-text)

Aging and osteoporosis contribute to decreased bone mass and bone mineral density as well as compromised fracture healing rates and bone repair quality. Consequently, the purpose of this study was to determine if recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered in an injectable beta-tricalcium phosphate/collagen matrix would enhance tibial fracture healing in geriatric (>2 years of age), osteoporotic rats. A total of 80 rats were divided equally among four groups: Fracture alone; Fracture plus matrix; Fracture plus matrix and either 0.3 mg/mL or 1.0 mg/mL rhPDGF-BB. At 3 and 5 weeks, rats were euthanized and treatment outcome was assessed histologically, radiographically, biomechanically, and by micro-CT. Results indicated rhPDGF-BB-treated fractures in osteoporotic, geriatric rats caused a statistically significant time-dependent increase in torsional strength 5 weeks after treatment. The healed fractures were equivalent in torsional strength to the contralateral, unoperated tibiae. Data from the study are the first, to our knowledge, to underscore rhPDGF-BB efficacy in an injectable beta-tricalcium phosphate/collagen matrix accelerated fracture repair in a geriatric, osteoporotic rat model.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Tibial Fractures treatmentIDA 10449446associated with OsteoporosisRGD 
Tibial Fractures treatmentISOPDGFB (Homo sapiens)10449446; 10449446associated with OsteoporosisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdgfb  (platelet derived growth factor subunit B)

Genes (Mus musculus)
Pdgfb  (platelet derived growth factor, B polypeptide)

Genes (Homo sapiens)
PDGFB  (platelet derived growth factor subunit B)


Additional Information