RGD Reference Report - Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients. - Rat Genome Database

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Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.

Authors: Song, XN  Zhang, LQ  Liu, DG  Lin, J  Zheng, JD  Dai, DP  Hei, AL  Hayakawa, H  Sekiguchi, M  Cai, JP 
Citation: Song XN, etal., Neurochem Res. 2011 Aug;36(8):1558-65. doi: 10.1007/s11064-011-0484-4. Epub 2011 May 3.
RGD ID: 10449033
Pubmed: PMID:21538080   (View Abstract at PubMed)
DOI: DOI:10.1007/s11064-011-0484-4   (Journal Full-text)

Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the amount of 8-oxoguanine in RNA during aging. There were increased amounts of 8-oxoguanine in RNA in the CAl and CA3 subregions of hippocampi of 8- and 12-month-old SAMP8 mice, which exhibited early aging syndromes and declining learning and memory abilities compared to those of age-matched control SAMR1 mice. The expression levels of MTH1 in the hippocampi of 8- and 12-month-old SAMP8 mice were significantly lower than those of control mice. Therefore, in this mouse model, age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1. Increased amounts of 8-oxoguanine in the RNA, and decreased expression of MTH1 were also observed in the hippocampi of patients suffering from Alzheimer's disease. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 10449033protein:decreased expression:hippocampusRGD 
Alzheimer's disease  ISONUDT1 (Homo sapiens)10449033; 10449033protein:decreased expression:hippocampusRGD 
Premature Aging  ISONudt1 (Mus musculus)10449033; 10449033mRNA and protein:decreased expression:hippocampusRGD 
Premature Aging  IEP 10449033mRNA and protein:decreased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nudt1  (nudix hydrolase 1)

Genes (Mus musculus)
Nudt1  (nudix hydrolase 1)

Genes (Homo sapiens)
NUDT1  (nudix hydrolase 1)


Additional Information