RGD Reference Report - Changes of neuregulin-1 (NRG-1) expression in a rat model of overactive bladder induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive bladder? - Rat Genome Database

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Changes of neuregulin-1 (NRG-1) expression in a rat model of overactive bladder induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive bladder?

Authors: Jang, H  Han, DS  Yuk, SM 
Citation: Jang H, etal., BMC Urol. 2013 Oct 23;13:54. doi: 10.1186/1471-2490-13-54.
RGD ID: 10449030
Pubmed: (View Article at PubMed) PMID:24152577
DOI: Full-text: DOI:10.1186/1471-2490-13-54

BACKGROUND: To determine whether neuregulin-1(NRG-1) is a potential new biomarker of overactive bladder (OAB) induced by partial urethral obstruction in a rat model of OAB and to evaluate the urothelium as a therapeutic target of OAB. METHODS: Female Sprague-Dawley rats were separated into three 20-animal groups: normal, OAB, and 5-hydroxymethyl tolterodine (5-HMT)-treated OAB. In the OAB and OAB + 5-HMT groups, the urethra of each animal was partially obstructed; the OAB + 5-HMT group received intravenous 5-HMT for 3 weeks. At the conclusion of the 5-HMT dosing, the rats in each group underwent cystometrography, and the bladders were histologically evaluated. The expression of brain derived-neurotrophic factor (BDNF) and NRG-1 were evaluated in the urothelium. RESULTS: Compared with the control group, the OAB group showed a markedly increased bladder weight and a significant decrease in the micturition interval and volume; rats in the OAB + 5-HMT group showed decreased bladder weights and an improved micturition interval and volume. BDNF and NRG-1 were expressed at significantly higher levels in the OAB group, and were significantly reduced in the OAB + 5-HMT group compared with the control group. CONCLUSIONS: The study suggests that NRG-1 is a potential new biomarker of OAB; the urothelium might be a therapeutic target for OAB treatment.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nrg1  (neuregulin 1)

Genes (Mus musculus)
Nrg1  (neuregulin 1)

Genes (Homo sapiens)
NRG1  (neuregulin 1)


Additional Information