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[Pulmonary expression of Nr1d1 in rats with ventilation-induced lung injury].

Authors: Hu, J  Wang, C 
Citation: Hu J and Wang C, Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1544-6.
Pubmed: (View Article at PubMed) PMID:24144766

OBJECTIVE: To investigate the changes in the expression of nuclear receptor subfamily1 (Nr1d1) in the lungs of rats with ventilation-induced lung injury and explore the molecular mechanism. METHODS: Seventy-two rats were randomly divided into 4 groups for observation at 4 time points (1:00 AM, 7:00 AM, 1:00 PM and 7:00 PM), and each group was further divided into 3 subgroups (Group FB, Group LV and Group HV). After ventilation for 3 h, the rats were sacrificed and lung tissue samples were obtained for testing the expression of Nr1d1 using gene chip technology and RT-PCR. RESULTS: Nr1d1 gene expression was down-regulated in HV group as shown by gene chip RT-PCR data. Cosine analysis showed that Nr1d1 expression exhibited a rhythmicity in FB group (P<0.05). CONCLUSION: The rhythmicity of Nr1d1 expression disappears as the tidal volume the increase. Diminished Nr1d1 expression is closely correlated with ventilation-induced lung injury in rats.


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RGD Object Information
RGD ID: 10448984
Created: 2015-12-10
Species: All species
Last Modified: 2015-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.