RGD Reference Report - Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats. - Rat Genome Database

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Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.

Authors: Chang, T  Wu, L  Wang, R 
Citation: Chang T, etal., Am J Hypertens. 2006 Jul;19(7):678-85.
RGD ID: 10412046
Pubmed: PMID:16814121   (View Abstract at PubMed)
DOI: DOI:10.1016/j.amjhyper.2006.01.014   (Journal Full-text)

Correlation of blood pressure (BP) with expression levels of large-conductance, voltage- and Ca2+-activated K+ (BK) channel beta1 subunit in vascular tissues from spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD) at different ages was investigated. Systolic BP and BK beta1 expression in mesenteric arteries at either mRNA or protein levels were not different among 4-week-old SHR, WKY, and SD. With hypertension developed at 7 weeks and reached plateau at 12 weeks, expression levels of BK beta1 mRNA in mesenteric arteries and aortae from SHR during this period of time were significantly higher than in age-matched normotensive WKY. The BK beta1 protein expression was significantly higher in mesenteric arteries from 12-week-old but not 7-week-old SHR when compared with age-matched WKY and SD. The BK beta1 protein levels in aortae were not different among 7-week-old SHR, WKY, and SD but were significantly lower in 12-week-old WKY than in age-matched SHR and SD. Captopril treatment normalized BP of 12-week-old SHR. This treatment downregulated BK beta1 protein in mesenteric arteries but upregulated it in aortae. No significant difference in BK alpha subunit expression was detected in mesenteric arteries from three strains of rats as well as the captopril-treated SHR. It appears that expression patterns of BK beta1 in vascular tissues vary depending on tissue types, animal age, and animal strains. Expression of BK beta1 in mesenteric arteries is closely correlated with BP in SHR. Increased BK beta1 expression in mesenteric arteries may represent a compensatory reaction to limit the development of hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  ISOKcnmb1 (Rattus norvegicus)10412046; 10412046mRNA more ...RGD 
hypertension  IEP 10412046mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnmb1  (potassium calcium-activated channel subfamily M regulatory beta subunit 1)

Genes (Mus musculus)
Kcnmb1  (potassium large conductance calcium-activated channel, subfamily M, beta member 1)

Genes (Homo sapiens)
KCNMB1  (potassium calcium-activated channel subfamily M regulatory beta subunit 1)


Additional Information