RGD Reference Report - Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of alpha- and beta1-subunit expression. - Rat Genome Database

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Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of alpha- and beta1-subunit expression.

Authors: Shi, L  Liu, X  Li, N  Liu, B  Liu, Y 
Citation: Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
RGD ID: 10412028
Pubmed: PMID:24051206   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mad.2013.09.001   (Journal Full-text)

Vascular disease increases in incidence with age and is the commonest cause of morbidity and mortality among elderly people. Large-conductance Ca(2+)-activated K(+)(MaxiK) channel, with pore-forming alpha-subunit and modulatory beta1-subunit, is a key regulator of vascular tone. This study explored functional and molecular evidence of MaxiK alteration with aging in the mesenteric artery(MA). Young, Middle-aged, and Old male Wistar rats were used. Selective MaxiK channel blocker (Iberiotoxin) induced a significant increase of vascular tension in MA in all three age groups. However, these effects were greatly decreased in Old animals. The amplitude and frequency of spontaneous transient outward currents were significantly decreased with aging. Single channel recording revealed that aging induced a decrease of the open probability and the mean open time, but an increase of the mean closed time of MaxiK channel. The Ca(2+)/voltage sensitivity of MaxiK was also decreased. Western blotting showed that the protein expression of MaxiK beta1- and alpha-subunit was significantly reduced with aging, and the suppression of beta1 subunits was larger than that of alpha subunits. These data suggest that aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of alpha- and beta1-subunit expression.

Objects referenced in this article
Gene Kcnma1 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus
Gene Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Rattus norvegicus

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