RGD Reference Report - A role for huntington disease protein in dendritic RNA granules. - Rat Genome Database

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A role for huntington disease protein in dendritic RNA granules.

Authors: Savas, JN  Ma, B  Deinhardt, K  Culver, BP  Restituito, S  Wu, L  Belasco, JG  Chao, MV  Tanese, N 
Citation: Savas JN, etal., J Biol Chem. 2010 Apr 23;285(17):13142-53. doi: 10.1074/jbc.M110.114561. Epub 2010 Feb 25.
RGD ID: 10403027
Pubmed: PMID:20185826   (View Abstract at PubMed)
PMCID: PMC2857123   (View Article at PubMed Central)
DOI: DOI:10.1074/jbc.M110.114561   (Journal Full-text)

Regulated transport and local translation of mRNA in neurons are critical for modulating synaptic strength, maintaining proper neural circuitry, and establishing long term memory. Neuronal RNA granules are ribonucleoprotein particles that serve to transport mRNA along microtubules and control local protein synthesis in response to synaptic activity. Studies suggest that neuronal RNA granules share similar structures and functions with somatic P-bodies. We recently reported that the Huntington disease protein huntingtin (Htt) associates with Argonaute (Ago) and localizes to cytoplasmic P-bodies, which serve as sites of mRNA storage, degradation, and small RNA-mediated gene silencing. Here we report that wild-type Htt associates with Ago2 and components of neuronal granules and co-traffics with mRNA in dendrites. Htt was found to co-localize with RNA containing the 3'-untranslated region sequence of known dendritically targeted mRNAs. Knockdown of Htt in neurons caused altered localization of mRNA. When tethered to a reporter construct, Htt down-regulated reporter gene expression in a manner dependent on Ago2, suggesting that Htt may function to repress translation of mRNAs during transport in neuronal granules.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HttRatregulation of intracellular mRNA localization  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htt  (huntingtin)


Additional Information