RGD Reference Report - Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats. - Rat Genome Database

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Inhibition of fibroblast growth factor receptor 1: influence on tympanic membrane wound healing in rats.

Authors: Kaftan, H  Reuther, L  Miehe, B  Hosemann, W  Beule, A 
Citation: Kaftan H, etal., Eur Arch Otorhinolaryngol. 2012 Jan;269(1):87-92. doi: 10.1007/s00405-011-1627-6. Epub 2011 May 18.
RGD ID: 10402099
Pubmed: (View Article at PubMed) PMID:21590482
DOI: Full-text: DOI:10.1007/s00405-011-1627-6

An animal model of chronic tympanic membrane (TM) perforation is needed for experiments on supporting healing of TM perforations. The basic fibroblast growth factor is important in TM wound healing. The object of this study was to investigate the efficacy of fibroblast growth factor receptor 1 (FGFR1) inhibition to arrest wound healing of experimental TM perforation. Bilateral instrumental myringotomies were performed in 12 rats. A specific inhibitor of the FGFR1 tyrosine kinase (SU5402) was applied to the left TM (2 mg/ml) and to the right TM (10 mg/ml) of each animal daily for 12 consecutive days. Thereafter, TMs were observed weekly for a total of 30 days. TM healing was delayed in a dose-dependent manner. We observed differences in the histologic parameters between both groups. SU 5402 is a strong inhibitor of TM healing but seems not to be suitable to create a chronic TM perforation in rat.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Fgfr1  (Fibroblast growth factor receptor 1)

Genes (Mus musculus)
Fgfr1  (fibroblast growth factor receptor 1)

Genes (Homo sapiens)
FGFR1  (fibroblast growth factor receptor 1)


Additional Information