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Circadian rhythms and light responsiveness of mammalian clock gene, Clock and BMAL1, transcripts in the rat retina.

Authors: Namihira, M  Honma, S  Abe, H  Tanahashi, Y  Ikeda, M  Honma, K 
Citation: Namihira M, etal., Neurosci Lett. 1999 Aug 13;271(1):1-4.
Pubmed: (View Article at PubMed) PMID:10471199

Circadian expression and light-responsiveness of the mammalian clock genes, Clock and BMAL1, in the rat retina were examined by in situ hydbribization under constant darkness. A small but significant daily variation was detected in the Clock transcript level, but not in BMAL1. Light increased the Clock and BMAL1 expressions significantly when examined 60 min after exposure. The light-induced gene expression was phase-dependent for Clock and peaked at ZT2, while rather constant throughout the day for BMAL1. These findings suggest that Clock and BMAL1 play different roles in the generation of circadian rhytm in the retina from those in the suprachiasmatic nucleus. Different roles are also suggested between the two genes in the photic signal transduction in the retina.


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RGD Object Information
RGD ID: 10401879
Created: 2015-10-09
Species: All species
Last Modified: 2015-10-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.