RGD Reference Report - The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin. - Rat Genome Database

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The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin.

Authors: Dzwonek, A  Mikula, M  Ostrowski, J 
Citation: Dzwonek A, etal., FEBS Lett. 2006 Mar 20;580(7):1839-45. Epub 2006 Feb 24.
RGD ID: 10401105
Pubmed: PMID:16519889   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2006.02.043   (Journal Full-text)

Heterogeneous nuclear ribonucleoprotein K (hnRNP K protein) is an RNA/DNA-binding protein that acts in several compartments, including mitochondria. It integrates cellular signaling cascades with multiple processes of gene expression mechanisms. Our studies demonstrate that: (1) insulin activates the import of hnRNP K protein into mitochondria in vitro and in vivo; (2) overexpression of hnRNP K protein modulates insulin-activated mitochondrial gene expression; and (3) insulin treatment stimulates binding of hnRNP K protein to mitochondrial DNA. Based on these and our previously reported results we conclude that hnRNP K protein may be a mediator of mitochondrial response to insulin.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
double-stranded DNA binding  IDA 10401105 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)


Additional Information