RGD Reference Report - Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia.

Authors: Nishijima, H  Arai, A  Kimura, T  Mori, F  Yamada, J  Migita, K  Wakabayashi, K  Baba, M  Ueno, S  Tomiyama, M 
Citation: Nishijima H, etal., Neuropathology. 2013 Aug;33(4):391-6. doi: 10.1111/neup.12009. Epub 2012 Dec 13.
RGD ID: 10398811
Pubmed: PMID:23241013   (View Abstract at PubMed)
DOI: DOI:10.1111/neup.12009   (Journal Full-text)

Levodopa-induced dyskinesia has been suggested to result from maladaptive plasticity at corticostriatal synapses. Synaptic plasticity is based upon morphologic changes of dendritic spines. To elucidate whether the morphologic changes of spines occur in the striatum of rat models of levodopa-induced dyskinesia, we examined immunoreactivity of drebrin, an actin-binding protein localized in dendritic spines of excitatory synapses, using 6-hydroxydopamine-lesioned rats repeatedly treated with levodopa. The cross-sectional area of drebrin-immunoreactive organelles, putative spines, in the dopamine-denervated striatum of the levodopa-induced dyskinesia model was greater than that of the Parkinson's disease model. Immunoelectron microscopic examinations confirmed that drebrin-immunoreactive spines became enlarged in the dopamine-denervated striatum of the levodopa-induced dyskinesia model, but not in the Parkinson's disease model. These results suggest that the development of levodopa-induced dyskinesia is associated with enlargement of dendritic spines at corticostriatal excitatory synapses.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Drug-Induced Dyskinesia  ISODbn1 (Rattus norvegicus)10398811; 10398811levodopainduced and protein:increased expression:striatum:RGD 
Drug-Induced Dyskinesia  IEP 10398811levodopainduced and protein:increased expression:striatum:RGD 
Parkinson's disease treatmentISODbn1 (Rattus norvegicus)10398811; 10398811levodopainduced and protein:increased expression:striatum:RGD 
Parkinson's disease treatmentIEP 10398811levodopainduced and protein:increased expression:striatum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dbn1  (drebrin 1)

Genes (Mus musculus)
Dbn1  (drebrin 1)

Genes (Homo sapiens)
DBN1  (drebrin 1)


Additional Information