RGD Reference Report - Gastroprotection studies of Schiff base zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats. - Rat Genome Database

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Gastroprotection studies of Schiff base zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats.

Authors: Golbabapour, S  Gwaram, NS  Hassandarvish, P  Hajrezaie, M  Kamalidehghan, B  Abdulla, MA  Ali, HM  Hadi, AH  Majid, NA 
Citation: Golbabapour S, etal., PLoS One. 2013 Sep 13;8(9):e75036. doi: 10.1371/journal.pone.0075036. eCollection 2013.
RGD ID: 10058975
Pubmed: PMID:24058648   (View Abstract at PubMed)
PMCID: PMC3772879   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0075036   (Journal Full-text)

BACKGROUND: The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats. METHODOLOGY/PRINCIPAL FINDING: The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.790x10(-5) M/kg) was used as a reference medicine. The pre-treatment with the zinc (II) complex (2.181x10(-5) and 4.362x10(-5) M/kg) protected the gastric mucosa similar to the reference control. They significantly increased the activity levels of nitric oxide, catalase, superoxide dismutase, glutathione and prostaglandin E2, and decreased the level of malondialdehyde. The histology assessments confirmed the protection through remarkable reduction of mucosal lesions and increased the production of gastric mucosa. Immunohistochemistry and western blot analysis indicated that the complex might induced Hsp70 up-regulation and Bax down-regulation. The complex moderately increased the gastroprotectiveness in fine fettle. The acute toxicity approved the non-toxic characteristic of the complex (<87.241x10(-5) M/kg). CONCLUSION/SIGNIFICANCE: The gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70. The gastric wall mucus was also a remarkable protective mechanism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BAXHumanGastrointestinal Hemorrhage treatmentISOBax (Rattus norvegicus) RGD 
BaxRatGastrointestinal Hemorrhage treatmentIEP  RGD 
BaxMouseGastrointestinal Hemorrhage treatmentISOBax (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bax  (BCL2 associated X, apoptosis regulator)

Genes (Mus musculus)
Bax  (BCL2-associated X protein)

Genes (Homo sapiens)
BAX  (BCL2 associated X, apoptosis regulator)


Additional Information