RGD Reference Report - Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium. - Rat Genome Database

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Venlafaxine modulates depression-induced behaviour and the expression of Bax mRNA and Bcl-xl mRNA in both hippocampus and myocardium.

Authors: Wang, Y  Xiao, Z  Liu, X  Berk, M 
Citation: Wang Y, etal., Hum Psychopharmacol. 2011 Mar;26(2):95-101. doi: 10.1002/hup.1177. Epub 2011 Feb 9.
RGD ID: 10054142
Pubmed: PMID:21308783   (View Abstract at PubMed)
DOI: DOI:10.1002/hup.1177   (Journal Full-text)

OBJECTIVES: Major depressive disorder is associated with progressive brain changes and is frequently comorbid with cardiovascular disease. There may be shared pathophysiological pathways between cerebral and myocardial dysfunction that impact on apoptosis related proteins. Our aim was to examine behaviour changes of rats with chronic mild stress (CMS), explore the expression of Bax and Bcl-xl in the hippocampus and myocardium, and additionally evaluate the effects of venlafaxine on these molecular mechanisms. METHODS: Rats were randomly divided into three groups. The behaviour was assessed using the open field and sucrose consumption tests. Gene expression was measured by RT-PCR. RESULTS: In CMS, there was a significant reduction of movements and sucrose consumption, an increased Bax level and a decreased Bcl-xl level in both the hippocampus and myocardium. The venlafaxine group showed an increase in movements and sucrose consumption, as well as upregulated expression of Bcl-xl and downregulated expression of Bax in both the hippocampus and myocardium. CONCLUSIONS: These results demonstrate that in CMS, there is an increase in pro-apoptotic pathways that is reversed by venlafaxine. This suggests that there are shared active biochemical pathways that may play a role in the process of neuroprogression that is seen in depression and cardiovascular disorders.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BAXHumandepressive disorder treatmentISOBax (Rattus norvegicus) RGD 
BCL2L1Humandepressive disorder treatmentISOBcl2l1 (Rattus norvegicus) RGD 
BaxRatdepressive disorder treatmentIEP  RGD 
BaxMousedepressive disorder treatmentISOBax (Rattus norvegicus) RGD 
Bcl2l1Ratdepressive disorder treatmentIEP  RGD 
Bcl2l1Mousedepressive disorder treatmentISOBcl2l1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bax  (BCL2 associated X, apoptosis regulator)
Bcl2l1  (Bcl2-like 1)

Genes (Mus musculus)
Bax  (BCL2-associated X protein)
Bcl2l1  (BCL2-like 1)

Genes (Homo sapiens)
BAX  (BCL2 associated X, apoptosis regulator)
BCL2L1  (BCL2 like 1)


Additional Information