RGD Reference Report - Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension.

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Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension.
Authors:	Redina, OE Smolenskaya, SE Maslova, LN Markel, AL
Citation:	Redina OE, etal., Clin Exp Hypertens. 2010;32(6):364-71. doi: 10.3109/10641961003628502.
RGD ID:	10053640
Pubmed:	PMID:21029000 (View Abstract at PubMed)
DOI:	DOI:10.3109/10641961003628502 (Journal Full-text)
The genetic background of the regulatory systems of the hypothalamic-pituitary-adrenal (HPA) axis in hypertension remains unclear. The inherited stress-induced arterial hypertension (ISIAH) and Wistar Albino Glaxo (WAG) normotensive rats were bred and their F(2) progeny were used in a quantitative trait loci (QTL) analysis to identify genomic regions for plasma basal and stress-induced corticosterone levels, and for absolute and relative adrenal gland weights. The significant loci were found for stress-induced corticosterone on chromosome 9 and for adrenal weight on chromosome 6. The results may help to identify the genes controlling the trait phenotypes in the ISIAH rats characterized by the enhanced responsiveness to stressful stimulation.

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Disease Annotations

Stress-Induced Hypertension (IAGP)

Phenotype Annotations

Mammalian Phenotype

abnormal adrenal gland weight (IDA)

abnormal circulating corticosterone level (IDA)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Strains with Phenominer Data

Strains with phenominer data

ISIAH

WAG/Nov

Objects Annotated

QTLs

Gmadr2 (Adrenal mass QTL 2)

Gmadr3 (Adrenal mass QTL 3)

Gmadr4 (Adrenal mass QTL 4)

Gmadr5 (Adrenal mass QTL 5)

Gmadr6 (Adrenal mass QTL 6)

Gmadr7 (Adrenal mass QTL 7)

Scort23 (Serum corticosterone level QTL 23)

Scort24 (Serum corticosterone level QTL 24)

Scort25 (Serum corticosterone level QTL 25)

Scort26 (Serum corticosterone level QTL 26)

Scort27 (Serum corticosterone level QTL 27)

Scort28 (Serum corticosterone level QTL 28)

Srcrt6 (Stress Responsive Cort QTL 6)

Srcrt7 (Stress Responsive Cort QTL 7)

Srcrt8 (Stress Responsive Cort QTL 8)

Srcrt9 (Stress Responsive Cort QTL 9)

Strains

ISIAH (Inherited stress-induced arterial hypertension)

WAG/Nov (NA)

Objects referenced in this article

QTL	Anxrr23	Anxiety related response QTL 23	Rattus norvegicus
QTL	Anxrr4	Anxiety related response QTL 4	Rattus norvegicus
QTL	Anxrr5	Anxiety related response QTL 5	Rattus norvegicus
QTL	Anxrr8	Anxiety related response QTL 8	Rattus norvegicus
QTL	Srcrt4	Stress Responsive Cort QTL 4	Rattus norvegicus
QTL	Thshl1	Thyroid stimulating hormone level QTL 1	Rattus norvegicus
QTL	Thshl2	Thyroid stimulating hormone level QTL 2	Rattus norvegicus

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Genetic control of the corticosterone level at rest and under emotional stress in ISIAH rats with inherited stress-induced arterial hypertension.

Mammalian Phenotype

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