RGD Reference Report - The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration. - Rat Genome Database

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The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration.

Authors: Vadhvani, M  Schwedhelm-Domeyer, N  Mukherjee, C  Stegmuller, J 
Citation: Vadhvani M, etal., PLoS One. 2013;8(2):e57530. doi: 10.1371/journal.pone.0057530. Epub 2013 Feb 28.
RGD ID: 10047221
Pubmed: (View Article at PubMed) PMID:23469015
DOI: Full-text: DOI:10.1371/journal.pone.0057530

Neuronal development requires proper migration, polarization and establishment of axons and dendrites. Growing evidence identifies the ubiquitin proteasome system (UPS) with its numerous components as an important regulator of various aspects of neuronal development. F-box proteins are interchangeable subunits of the Cullin-1 based E3 ubiquitin ligase, but only a few family members have been studied. Here, we report that the centrosomal E3 ligase FBXO31-SCF (Skp1/Cullin-1/F-box protein) regulates neuronal morphogenesis and axonal identity. In addition, we identified the polarity protein Par6c as a novel interaction partner and substrate targeted for proteasomal degradation in the control of axon but not dendrite growth. Finally, we ascribe a role for FBXO31 in dendrite growth and neuronal migration in the developing cerebellar cortex. Taken together, we uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator of neuronal development.

Annotation

Gene Ontology Annotations    

Biological Process

Cellular Component
centrosome  (IDA)

Objects Annotated

Genes (Rattus norvegicus)
Fbxo31  (F-box protein 31)


Additional Information