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Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation.

Authors: Hunter, AL  Zhang, J  Chen, SC  Si, X  Wong, B  Ekhterae, D  Luo, H  Granville, DJ 
Citation: Hunter AL, etal., FEBS Lett. 2007 Mar 6;581(5):879-84. Epub 2007 Feb 2.
Pubmed: (View Article at PubMed) PMID:17292893
DOI: Full-text: DOI:10.1016/j.febslet.2007.01.050

Apoptosis repressor with caspase recruitment domain (ARC), an anti-apoptotic protein, is highly expressed in differentiated heart and skeletal muscle. Apoptosis and differentiation share numerous common pathways; therefore, we examined the impact of ARC on H9c2-myoblast differentiation. We demonstrate that ARC expression levels increase and stabilize upon differentiation. ARC-overexpression in pre-differentiated H9c2-cells suppresses differentiation; indicated by increased myotube formation, nuclear fusion and expression of the differentiation markers myogenin and troponin-T. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. In summary, we show a novel role for ARC in the regulation of muscle differentiation.


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RGD Object Information
RGD ID: 10047212
Created: 2015-07-11
Species: All species
Last Modified: 2015-07-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.