RGD Reference Report - [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. - Rat Genome Database

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[Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy].

Authors: Li, YQ  Gao, GD  Chu, YL  Gong, XH 
Citation: Li YQ, etal., Sheng Li Xue Bao. 1998 Jun;50(3):303-8.
RGD ID: 10047105
Pubmed: PMID:11324571   (View Abstract at PubMed)

Using reverse transcriptase-polymerase chain reaction (RT-PCR) the changes of the angiotensin II receptor subtype 1-a (AT1a) and 1-b (AT1b) mRNA levels were examined in hypertrophied ventricles caused by ventral aorta-caval fistula of SD rats. The results show as follows. (1) Three days after operation, the ventricular weight increased significantly, whereas the level of AT1a and AT1b mRNA in both ventricles remained unchanged. (2) Twelve days after operation, the weight increase of both ventricles was more evident, the levels of AT1a and AT1b mRNA in the right ventricle increased (by 62.6% and 72.0%), as compared with control. In the left ventricle, on the other hand, the level of AT1a mRNA increased by 79.0%, while the level of AT1b mRNA showed no obvious increase. (3) Thirty-five days after operation, the levels of AT1a and AT1b mRNA in both ventricles increased still more significant, (i.e., 70.0% and 83.9% in the right and 96.5% and 86.9% in the left). Moreover, 12 d and 35 d after operation, the level of AT1a mRNA was higher than that of AT1b mRNA in both ventricles. (4) There was a positive correlation between the degree of ventricular hypertrophy with the level of AT1 mRNA in ventricular myocardium (r = 0.6168-0.8223). The results suggest that the increased mRNA expression of AT1 in myocardial hypertrophy caused by volume overload may be a mechanism underlying the increased responsiveness of hypertrophic myocardial cells to Ang II, and a difference in the expression between AT1a and AT1b mRNAs in myocardial hypertrophy may be related to the different physiological or pathophysiological roles of Ang II, mediated by the two subtypes of AT1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cardiomegaly  ISOAgtr1a (Rattus norvegicus)10047105; 10047105 RGD 
Cardiomegaly  IEP 10047105; 10047105 RGD 
Cardiomegaly  ISOAgtr1b (Rattus norvegicus)10047105 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agtr1a  (angiotensin II receptor, type 1a)
Agtr1b  (angiotensin II receptor, type 1b)

Genes (Mus musculus)
Agtr1a  (angiotensin II receptor, type 1a)
Agtr1b  (angiotensin II receptor, type 1b)

Genes (Homo sapiens)
AGTR1  (angiotensin II receptor type 1)


Additional Information