RGD Reference Report - Increased dopamine release from rat striatal slices by inhibitors of GABA-aminotransferase. - Rat Genome Database

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Increased dopamine release from rat striatal slices by inhibitors of GABA-aminotransferase.

Authors: Stoof, JC  Mulder, AH 
Citation: Stoof JC and Mulder AH, Eur J Pharmacol. 1977 Nov 15;46(2):177-80.
RGD ID: 10047092
Pubmed: (View Article at PubMed) PMID:590329

The effects were examined of two inhibitors of GABA-aminotransferase, amino-oxyacetic acid (AOAA) and RMI-71645-16, on depolarization-induced (30 mM K+) dopamine (DA) release from rat striatal slices. When added to the medium, these drugs increased the release of radiolabeled DA, either accumulated by high-affinity uptake or synthesized from 14C-tyrosine. AOAA did not modify the release of 14C-acetylcholine from striatal slices or 3H-noradrenaline from cortical slices. Moreover, 3H-DA release from substantia nigra was not affected. The data suggest the possibility that the effects of GABA-T inhibitors on striatal DA release are mediated by intrinsic GABA-ergic neurons.

Annotation

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Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Abat  (4-aminobutyrate aminotransferase)


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