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Impact of estrogen receptor beta activation on functional recovery after experimental stroke.

Authors: Madinier, A  Wieloch, T  Olsson, R  Ruscher, K 
Citation: Madinier A, etal., Behav Brain Res. 2014 Mar 15;261:282-8. doi: 10.1016/j.bbr.2013.12.046. Epub 2014 Jan 6.
Pubmed: (View Article at PubMed) PMID:24406718
DOI: Full-text: DOI:10.1016/j.bbr.2013.12.046

Acute treatment with 17beta-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ERbeta) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ERbeta ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50 mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERbeta is involved in mechanisms of stroke recovery.


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RGD Object Information
RGD ID: 10045677
Created: 2015-06-16
Species: All species
Last Modified: 2015-06-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.