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The elongation, termination, and recycling phases of translation in eukaryotes.

Authors: Dever, TE  Green, R 
Citation: Dever TE and Green R, Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013706. doi: 10.1101/cshperspect.a013706.
Pubmed: (View Article at PubMed) PMID:22751155
DOI: Full-text: DOI:10.1101/cshperspect.a013706

This work summarizes our current understanding of the elongation and termination/recycling phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In addition to an overview of translation elongation, we discuss unique aspects of eukaryotic translation elongation including eEF1 recycling, eEF2 modification, and eEF3 and eIF5A function. Likewise, we highlight the function of the eukaryotic release factors eRF1 and eRF3 in translation termination, and the functions of ABCE1/Rli1, the Dom34:Hbs1 complex, and Ligatin (eIF2D) in ribosome recycling. Finally, we present some of the key questions in translation elongation, termination, and recycling that remain to be answered.

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RGD Object Information
RGD ID: 10044026
Created: 2015-06-01
Species: All species
Last Modified: 2015-06-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.