RGD Reference Report - TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. - Rat Genome Database

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TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons.

Authors: He, Z  Jia, C  Feng, S  Zhou, K  Tai, Y  Bai, X  Wang, Y 
Citation: He Z, etal., J Neurosci. 2012 Jul 4;32(27):9383-95. doi: 10.1523/JNEUROSCI.6363-11.2012.
RGD ID: 10044012
Pubmed: PMID:22764246   (View Abstract at PubMed)
PMCID: PMC6622237   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.6363-11.2012   (Journal Full-text)

Neurotrophin-3 (NT-3) plays numerous important roles in the CNS and the elevation of intracellular Ca(2+) ([Ca(2+)](i)) is critical for these functions of NT-3. However, the mechanism by which NT-3 induces [Ca(2+)](i) elevation remains largely unknown. Here, we found that transient receptor potential canonical (TRPC) 5 protein and TrkC, the NT-3 receptor, exhibited a similar temporal expression in rat hippocampus and cellular colocalization in hippocampal neurons. Stimulation of the neurons by NT-3 induced a nonselective cation conductance and PLCgamma-dependent [Ca(2+)](i) elevation, which were both blocked when TRPC5, but not TRPC6 channels, were inhibited. Moreover, the Ca(2+) influx through TRPC5 induced by NT-3 inhibited the neuronal dendritic growth through activation of calmodulin-dependent kinase (CaMK) IIalpha. In contrast, the Ca(2+) influx through TRPC6 induced by NT-4 promoted the dendritic growth. Thus, TRPC5 acts as a novel and specific mediator for NT-3 to regulate dendrite development through CaMKIIalpha.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Trpc5Ratdendrite  IDA  RGD 
Trpc5Ratneuronal cell body  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)
Plcg1  (phospholipase C, gamma 1)
Trpc5  (transient receptor potential cation channel, subfamily C, member 5)
Trpc6  (transient receptor potential cation channel, subfamily C, member 6)


Additional Information