RGD Reference Report - TRPA1 is a component of the nociceptive response to CO2. - Rat Genome Database

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TRPA1 is a component of the nociceptive response to CO2.

Authors: Wang, YY  Chang, RB  Liman, ER 
Citation: Wang YY, etal., J Neurosci. 2010 Sep 29;30(39):12958-63. doi: 10.1523/JNEUROSCI.2715-10.2010.
RGD ID: 10043825
Pubmed: PMID:20881114   (View Abstract at PubMed)
PMCID: PMC2993877   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.2715-10.2010   (Journal Full-text)

In humans, high concentrations of CO(2), as found in carbonated beverages, evoke a mixture of sensations that include a stinging or pungent quality. The stinging sensation is thought to originate with the activation of nociceptors, which innervate the respiratory, nasal, and oral epithelia. The molecular basis for this sensation is unknown. Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 gene. TRPA1 is sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2). CO(2) can diffuse into cells and produce intracellular acidification, which could gate TRPA1 channels. Consistent with this mechanism, TRPA1 channels in excised patches were activated in a dose-dependent manner by intracellular protons. We conclude that TRPA1, by sensing intracellular acidification, constitutes an important component of the nociceptive response to CO(2).

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to carbon dioxide  IDA 10043825 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Trpa1  (transient receptor potential cation channel, subfamily A, member 1)

Additional Information