RGD Reference Report - Prolongation of parturition in the pregnant rat following treatment with a platelet activating factor receptor antagonist. - Rat Genome Database

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Prolongation of parturition in the pregnant rat following treatment with a platelet activating factor receptor antagonist.

Authors: Zhu, YP  Hoffman, DR  Hwang, SB  Miyaura, S  Johnston, JM 
Citation: Zhu YP, etal., Biol Reprod. 1991 Jan;44(1):39-42.
RGD ID: 10041055
Pubmed: PMID:1849751   (View Abstract at PubMed)

The presence of platelet activating factor (PAF) in amniotic fluid of women only in labor is indicative of a role for PAF in parturition. In addition, stimulated amnion membrane produces both PAF and prostaglandin E2, each of which is capable of inducing myometrial contraction. To evaluate the involvement of PAF in the process of parturition, we administered the PAF receptor antagonist, L-659,989, to 17-day timed pregnant rats and followed the events of labor and delivery. Administration by mouth with L-659,989 of three concentrations (1.6, 16, and 48 mg/kg/day) did not alter the gestational period; however, the duration of parturition was increased from 2-fold to 5-fold by such treatment. No toxicity of the analog was apparent; treated dams showed no signs of morbidity, and fetal mortality was not significantly altered by treatment with the antagonist. Based on these experiments, it is suggested that the PAF receptor antagonist interferes with the normal progression of events of parturition and that PAF is an integral mediator in initiating the myometrial contraction necessary for expulsion of the fetus.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PtafrRatparturition  IMP  RGD 
PtafrRatpositive regulation of maternal process involved in parturition  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptafr  (platelet-activating factor receptor)


Additional Information