RGD Reference Report - [The expressions of periostin and the related factors during healing process of full-thickness cutaneous wound in rat]. - Rat Genome Database

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[The expressions of periostin and the related factors during healing process of full-thickness cutaneous wound in rat].

Authors: Hou, JJ  Nie, FF  Li, BL  Zhao, X  Qin, ZL  Ma, YG  Li, JN 
Citation: Hou JJ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Jun;24(6):334-7.
RGD ID: 10040991
Pubmed: PMID:22681660   (View Abstract at PubMed)

OBJECTIVE: To observe the expression of osteoblast-specific factor 2 (periostin, PN), angiopoietin-1 (Ang-1), vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 [VEGFR-2/fetal liver kinase-1 (FLK-1)] in wound surface and its peripheral skin, and their effects on wound healing in rats. METHODS: Forty-eight Sprague-Dawley (SD) rats were randomly divided into six groups, with 8 rats in each group. An area of 2 cmx2 cm full-thickness skin was excised on both sides of the back of rats. Specimens from wounds were obtained on 1, 4, 7, 10, 14, 21 days after operation, and histological evaluation and immunohistochemical staining of PN, Ang-1, VEGF and FLK-1 were made to determine their expression levels. Normal skin specimens were obtained as normal controls. RESULTS: The expressions of PN, Ang-1, VEGF and FLK-1 were significantly increased in wound surface after operation. Compared with the skin of normal controls, the expression of PN in the tissues of wound increased by 234.4% on the 1st day, and then increased continuously up to 597.9% on the 7th day (reaching the peak) after operation, followed by a decrease, the increase rate was 280.9% on the 21st day, and still remained at a high level (all P < 0.05). The expression of Ang-1 in the tissue of wound increased by 128.1% on the 1st day and 327.5% on the 4th day (reaching the peak), and then, it was gradually decreased. The increase rate was only 80.5% on the 14th day and it rose slightly later (all P < 0.05). The expression of VEGF in the tissues of wound reached the peak (165.8%) on the 7th day. Then it decreased with a slight fluctuation (all P < 0.05). The expression of FLK-1 in the tissues of wound was increased by 56.1% on the 1st day, and the level remained. It reached the peak by an increase of 70.1% on the 7th day (both P < 0.05). Then, it was lowered after the 10th day (all P > 0.05). CONCLUSIONS: The expressions of PN, Ang-1, VEGF, FLK-1 were obviously increased during healing of skin wound, with different peaking time and expressing rates. The increase in expression of PN showed the longest duration and highest peak value. The PN, Ang-1, VEGF, FLK-1 all play a role in the wound healing process, and PN might play an important role during the healing process of a full-thickness cutaneous wound.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Wounds and Injuries  ISOPostn (Rattus norvegicus)10040991; 10040991protein:increased expression:skin:RGD 
Wounds and Injuries  IEP 10040991protein:increased expression:skin:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Postn  (periostin)

Genes (Mus musculus)
Postn  (periostin, osteoblast specific factor)

Genes (Homo sapiens)
POSTN  (periostin)


Additional Information