RGD Reference Report - Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder. - Rat Genome Database

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Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder.

Authors: Rani, S  Barbe, MF  Barr, AE  Litvin, J 
Citation: Rani S, etal., J Histochem Cytochem. 2009 Nov;57(11):1061-73. doi: 10.1369/jhc.2009.954081. Epub 2009 Jul 20.
RGD ID: 10040958
Pubmed: PMID:19620321   (View Abstract at PubMed)
PMCID: PMC2762884   (View Article at PubMed Central)
DOI: DOI:10.1369/jhc.2009.954081   (Journal Full-text)

Work-related musculoskeletal disorders (WMSDs), also known as repetitive strain injuries of the upper extremity, frequently cause disability and impairment of the upper extremities. Histopathological changes including excess collagen deposition around myofibers, cell necrosis, inflammatory cell infiltration, and increased cytokine expression result from eccentric exercise, forced lengthening, exertion-induced injury, and repetitive strain-induced injury of muscles. Repetitive tasks have also been shown to result in tendon and neural injuries, with subsequent chronic inflammatory responses, followed by residual fibrosis. To identify mechanisms that regulate tissue repair in WMSDs, we investigated the induction of periostin-like factor (PLF) and periostin, proteins induced in other pathologies but not expressed in normal adult tissue. In this study, we examined the level of PLF and periostin in muscle, tendon, and nerve using immunohistochemistry and Western blot analysis. PLF increased with continued task performance, whereas periostin was constitutively expressed. PLF was located in satellite cells and/or myoblasts, which increased in number with continued task performance, supporting our hypothesis that PLF plays a role in muscle repair or regeneration. Periostin, on the other hand, was not present in satellite cells and/or myoblasts.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cumulative Trauma Disorders  ISOPostn (Rattus norvegicus)10040958; 10040958protein:increased expression:tendon more ...RGD 
Cumulative Trauma Disorders  IEP 10040958protein:increased expression:tendon more ...RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to muscle activity  IEP 10040958 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuromuscular junction  IDA 10040958 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Postn  (periostin)

Genes (Mus musculus)
Postn  (periostin, osteoblast specific factor)

Genes (Homo sapiens)
POSTN  (periostin)


Additional Information