RGD Reference Report - RNA pseudouridylation: new insights into an old modification. - Rat Genome Database

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RNA pseudouridylation: new insights into an old modification.

Authors: Ge, J  Yu, YT 
Citation: Ge J and Yu YT, Trends Biochem Sci. 2013 Apr;38(4):210-8. doi: 10.1016/j.tibs.2013.01.002. Epub 2013 Feb 4.
RGD ID: 10002759
Pubmed: PMID:23391857   (View Abstract at PubMed)
PMCID: PMC3608706   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tibs.2013.01.002   (Journal Full-text)

Pseudouridine is the most abundant post-transcriptionally modified nucleotide in various stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific isomerization, resulting in an extra hydrogen-bond donor that distinguishes it from other nucleotides. In eukaryotes, uridine-to-pseudouridine isomerization is catalyzed primarily by box H/ACA RNPs, ribonucleoproteins that act as pseudouridylases. When introduced into RNA, pseudouridine contributes significantly to RNA-mediated cellular processes. It was recently discovered that pseudouridylation can be induced by stress, suggesting a regulatory role for pseudouridine. It has also been reported that pseudouridine can be artificially introduced into mRNA by box H/ACA RNPs and that such introduction can mediate nonsense-to-sense codon conversion, thus demonstrating a new means of generating coding or protein diversity.


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