Pia1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Pia1 (Pristane induced arthritis QTL 1) Rattus norvegicus

Symbol: Pia1
Name: Pristane induced arthritis QTL 1
RGD ID: 61411
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: joint inflammation composite score   (CMO:0000919)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position No map positions available.
Cross Type: intercross
Strains Crossed: DA E3 



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition
pristane  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain
DA  (IEA)
E3  (IEA)

References

Related QTLs

Related QTL Description Reference
Aia1 interacts with RGD:61035
Eae1 maps to same region RGD:61031
Coreg1 maps to same region RGD:69708
Pia21 maps to same region RGD:61031


Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch

Additional Information

Database Acc Id Source(s)
NCBI Gene Pia1

RGD Curation Notes
Note Type Note Reference
qtl_general this reproduced QTL has a LOD of 4.8 and flanking markers D20Rat41 and D20Wox3 631850
qtl_general this QTL is reproduced with high significance by the generation of congenic strains 631850
qtl_general inflammation is restricted to joints and involves pannus formation, major histocompatibility complex (MHC) class II expression and T lymphocyte infiltration 61088
qtl_general after pristane injection an increase in the level of interleukin was seen but not during chronic arthritis 61088
qtl_general associates with the chronicity of arthritis 61089
qtl_general animals with RT1f haplotype showed significantly higher susceptibility 61088