GWAS1644371_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1644371_H (eosinophil count QTL GWAS1644371 (human)) Homo sapiens

Symbol: GWAS1644371_H
Name: eosinophil count QTL GWAS1644371 (human)
RGD ID: 597587511
Trait: eosinophil quantity   (VT:0002602)    
Measurement Type: blood eosinophil count   (CMO:0000033)    
LOD Score: Not Available
P Value: 6.0E-69
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3896,197,392 - 6,197,393RGD_MAPPER_PIPELINEGRCh38
GRCh3796,197,392 - 6,197,393RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1644371_HHumanblood eosinophil count  IAGPrs1888909405850206Based on the EFO term IDGWAS_CATALOGPMID:39024449

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1644371_HHumaneosinophil quantity  IAGPrs1888909405850206Based on the EFO term IDGWAS_CATALOGPMID:39024449

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1644371_HHumaneosinophil count  IAGPrs1888909405850206 GWAS_CATALOGPMID:39024449
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Vertebrate Trait

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs1888909)
Human AssemblyChrPosition (strand)Source
GRCh3896,197,392 - 6,197,393RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407381705GWAS1030681_HNasal Cavity Polyp QTL GWAS1030681 (human)7e-32Nasal Cavity Polyp961973926197393Human
597579295GWAS1636155_Heosinophil count QTL GWAS1636155 (human)8e-69eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
628963068GWAS2871297_Hallergic rhinitis QTL GWAS2871297 (human)9e-18allergic rhinitis961973926197393Human
407385934GWAS1034910_Heosinophil count QTL GWAS1034910 (human)4e-229eosinophil count961973926197393Human
597586969GWAS1643829_Heosinophil count QTL GWAS1643829 (human)1e-116eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
597613975GWAS1670835_Hasthma QTL GWAS1670835 (human)5e-31asthma961973926197393Human
407381954GWAS1030930_Heosinophil count QTL GWAS1030930 (human)3e-384eosinophil count961973926197393Human
628615293GWAS2523522_Heosinophil count QTL GWAS2523522 (human)3e-09eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
626447197GWAS2261130_Heosinophil count QTL GWAS2261130 (human)7e-125eosinophil count961973926197393Human
628990961GWAS2899190_HNasal polyposis QTL GWAS2899190 (human)2e-28Nasal polyposis961973926197393Human
597018264GWAS1114338_Heosinophil count QTL GWAS1114338 (human)4e-229eosinophil count961973926197393Human
628996336GWAS2904565_Hasthma, family history QTL GWAS2904565 (human)9e-13asthma, family history961973926197393Human
597614477GWAS1671337_HNasal polyposis QTL GWAS1671337 (human)2e-28Nasal polyposis961973926197393Human
2302773MAMTS18_HMammary tumor susceptibility QTL 18 (human)0.039Mammary tumor susceptibility9528914931289149Human
626441792GWAS2255725_Heosinophil count QTL GWAS2255725 (human)1e-395eosinophil count961973926197393Human
2293433PRSTS223_HProstate tumor susceptibility QTL 223 (human)1.6Prostate tumor susceptibility9528914931289149Human
616518179GWAS1914762_Heosinophil count QTL GWAS1914762 (human)2e-250eosinophil count961973926197393Human
597584702GWAS1641562_Hasthma QTL GWAS1641562 (human)5e-24asthma961973926197393Human
407418733GWAS1067709_HNasal Cavity Polyp QTL GWAS1067709 (human)1e-39Nasal Cavity Polyp961973926197393Human
597587511GWAS1644371_Heosinophil count QTL GWAS1644371 (human)6e-69eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
628429148GWAS2337377_Heosinophil count QTL GWAS2337377 (human)4e-229eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
597594800GWAS1651660_Heosinophil count QTL GWAS1651660 (human)7e-168eosinophil count961973926197393Human
628738632GWAS2646861_Heosinophil count QTL GWAS2646861 (human)9e-154eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
407053302GWAS702278_Heosinophil percentage of leukocytes QTL GWAS702278 (human)4e-255eosinophil percentage of leukocytes961973926197393Human
628983364GWAS2891593_Heosinophil count QTL GWAS2891593 (human)4e-143eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
2293400PRSTS224_HProstate tumor susceptibility QTL 224 (human)1.62Prostate tumor susceptibility9528914931289149Human
407384946GWAS1033922_Heosinophil count QTL GWAS1033922 (human)1e-395eosinophil count961973926197393Human
407386738GWAS1035714_Hchronic rhinosinusitis QTL GWAS1035714 (human)0.0000006chronic rhinosinusitis961973926197393Human
628550988GWAS2459217_Hlevel of bone marrow proteoglycan in blood QTL GWAS2459217 (human)3e-13level of bone marrow proteoglycan in blood961973926197393Human
597584933GWAS1641793_Heosinophil count QTL GWAS1641793 (human)2e-126eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
628814904GWAS2723133_Heosinophil count QTL GWAS2723133 (human)2e-250eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
597373023GWAS1469097_Hchronic rhinosinusitis QTL GWAS1469097 (human)0.0000006chronic rhinosinusitis961973926197393Human
617203842GWAS2184282_Hlevel of bone marrow proteoglycan in blood QTL GWAS2184282 (human)3e-13level of bone marrow proteoglycan in blood961973926197393Human
597613394GWAS1670254_Hasthma, family history QTL GWAS1670254 (human)9e-13asthma, family history961973926197393Human
626445210GWAS2259143_Heosinophil count QTL GWAS2259143 (human)3e-09eosinophil count961973926197393Human
597018203GWAS1114277_Heosinophil count QTL GWAS1114277 (human)3e-384eosinophil count961973926197393Human
597364810GWAS1460884_Heosinophil percentage of leukocytes QTL GWAS1460884 (human)4e-255eosinophil percentage of leukocytes961973926197393Human
597594826GWAS1651686_Heosinophil count QTL GWAS1651686 (human)3e-207eosinophil count961973926197393Human
597584586GWAS1641446_Hdrug use measurement, asthma QTL GWAS1641446 (human)5e-13drug use measurement, asthma961973926197393Human
628988971GWAS2897200_Hasthma QTL GWAS2897200 (human)5e-31asthma961973926197393Human
597444555GWAS1540629_Heosinophil count QTL GWAS1540629 (human)3e-09eosinophil count961973926197393Human
628983338GWAS2891567_Heosinophil count QTL GWAS2891567 (human)3e-207eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
2315898GLUCO191_HGlucose level QTL 191 (human)1.83Glucose level9528914931289149Human
407417746GWAS1066722_Heosinophil count QTL GWAS1066722 (human)3e-09eosinophil count961973926197393Human
616506077GWAS1902660_Hlevel of bone marrow proteoglycan in blood serum QTL GWAS1902660 (human)3e-13level of bone marrow proteoglycan in blood serum961973926197393Human
407404843GWAS1053819_Heosinophil count QTL GWAS1053819 (human)9e-154eosinophil count961973926197393Human
1357299AASTH47_HAllergic/atopic asthma related QTL 47 (human)0.00028Reversible airflow obstruction9528914931289149Human
597596276GWAS1653136_Heosinophil count QTL GWAS1653136 (human)4e-143eosinophil count961973926197393Human
628607004GWAS2515233_HNasal Cavity Polyp QTL GWAS2515233 (human)1e-39Nasal Cavity Polyp961973926197393Human
407398564GWAS1047540_Heosinophil count QTL GWAS1047540 (human)7e-125eosinophil count961973926197393Human
628427291GWAS2335520_Heosinophil count QTL GWAS2335520 (human)1e-395eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
626443065GWAS2256998_Heosinophil count QTL GWAS2256998 (human)9e-154eosinophil count961973926197393Human
597435372GWAS1531446_HNasal Cavity Polyp QTL GWAS1531446 (human)1e-39Nasal Cavity Polyp961973926197393Human
597393385GWAS1489459_Heosinophil count QTL GWAS1489459 (human)1e-395eosinophil count961973926197393Human
626444068GWAS2258001_Heosinophil count QTL GWAS2258001 (human)4e-229eosinophil count961973926197393Human
628982031GWAS2890260_Heosinophil count QTL GWAS2890260 (human)7e-168eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
597423080GWAS1519154_Heosinophil count QTL GWAS1519154 (human)9e-154eosinophil count961973926197393Human
628429958GWAS2338187_Heosinophil count QTL GWAS2338187 (human)3e-384eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
1643245BW137_HBody weight QTL 137 (human)2.28Body weight9528914931289149Human
597590891GWAS1647751_Hallergic rhinitis QTL GWAS1647751 (human)9e-18allergic rhinitis961973926197393Human
597507562GWAS1603636_Heosinophil count QTL GWAS1603636 (human)7e-125eosinophil count961973926197393Human
597373027GWAS1469101_HNasal Cavity Polyp QTL GWAS1469101 (human)7e-32Nasal Cavity Polyp961973926197393Human
626444717GWAS2258650_Heosinophil count QTL GWAS2258650 (human)3e-384eosinophil count961973926197393Human
597586402GWAS1643262_Heosinophil count QTL GWAS1643262 (human)3e-130eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
628441609GWAS2349838_Heosinophil percentage of leukocytes QTL GWAS2349838 (human)4e-255eosinophil quantity (VT:0002602)blood eosinophil count to total leukocyte count ratio (CMO:0000369)961973926197393Human
628891777GWAS2800006_Heosinophil count QTL GWAS2800006 (human)7e-125eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human
597588192GWAS1645052_Heosinophil count QTL GWAS1645052 (human)1e-147eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)961973926197393Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS1636155_H GCST90479606 eosinophil (fraction, minimum, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals T 0.3136 8E-69 68.097 rs1888909 0.05199 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1641446_H GCST90479584 Takes medication for asthma? 4,269 African American or Afro-Caribbean cases, 51,236 African American or Afro-Caribbean controls, 2,023 Hispanic or Latin American cases, 27,291 Hispanic or Latin American controls, 263 East Asian ancestry cases, 3,284 East Asian ancestry controls, 18,629 European ancestry cases, 297,039 European ancestry controls T 0.2998 5E-13 12.302 rs1888909 0.07927 drug use measurement (EFO:0007010)
 PMID:39024449
GWAS1641562_H GCST90479585 Asthma 5,678 African American or Afro-Caribbean cases, 49,827 African American or Afro-Caribbean controls, 2,887 Hispanic or Latin American cases, 26,427 Hispanic or Latin American controls, 388 East Asian ancestry cases, 3,159 East Asian ancestry controls, 26,657 European ancestry cases, 289,011 European ancestry controls T 0.2998 5E-24 23.302 rs1888909 0.09777 PMID:39024449
GWAS1641793_H GCST90479602 eosinophil (absolute count, mean, inv-norm transformed) 90,448 African American or Afro-Caribbean individuals, 42,397 Hispanic or Latin American individuals, 3,996 East Asian ancestry individuals, 310,757 European ancestry individuals T 0.3144 2E-126 125.699 rs1888909 0.08301 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1643262_H GCST90479604 eosinophil (fraction, maximum, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals T 0.3136 3E-130 129.523 rs1888909 0.07953 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1643829_H GCST90479601 eosinophil (absolute count, maximum, inv-norm transformed) 90,403 African American or Afro-Caribbean individuals, 42,380 Hispanic or Latin American individuals, 3,995 East Asian ancestry individuals, 310,588 European ancestry individuals T 0.3144 1E-116 116 rs1888909 0.07738 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1644371_H GCST90479603 eosinophil (absolute count, minimum, inv-norm transformed) 90,479 African American or Afro-Caribbean individuals, 42,403 Hispanic or Latin American individuals, 3,997 East Asian ancestry individuals, 310,849 European ancestry individuals T 0.3144 6E-69 68.222 rs1888909 0.05105 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS1645052_H GCST90479605 eosinophil (fraction, mean, inv-norm transformed) 98,055 African American or Afro-Caribbean individuals, 47,410 Hispanic or Latin American individuals, 4,652 East Asian ancestry individuals, 335,542 European ancestry individuals T 0.3136 1E-147 147 rs1888909 0.08835 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS2335520_H GCST90002302 Eosinophil count 583,850 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals C 0.773068 1E-395 395 rs1888909 N/A eosinophil count (EFO:0004842)
 PMID:32888493
GWAS2337377_H GCST90002381 Eosinophil count 408,112 British individuals C 0.744314 4E-229 228.398 rs1888909 0.08715122 eosinophil count (EFO:0004842)
 PMID:32888494
GWAS2338187_H GCST90002298 Eosinophil count 474,237 European ancestry individuals C 0.744354 3E-384 383.523 rs1888909 0.095262 eosinophil count (EFO:0004842)
 PMID:32888493
GWAS2349838_H GCST90002382 Eosinophil percentage of white cells 408,112 British individuals C 0.744298 4E-255 254.398 rs1888909 0.08975637 eosinophil percentage of leukocytes (EFO:0007991)
 PMID:32888494
GWAS2459217_H GCST90470322 PRG2 protein levels 47,745 European ancestry individuals C 0.7474701 3E-13 12.523 rs1888909 0.04290099 level of bone marrow proteoglycan in blood (OBA:2050844)
 PMID:39789286
GWAS2515233_H GCST90018883 Nasal polyps 5,093 European ancestry cases, 444,966 European ancestry controls, 160 East Asian ancestry cases, 151,846 East Asian ancestry controls C NR 1E-39 39 rs1888909 0.3161 Nasal Cavity Polyp (EFO:1000391)
 PMID:34594039
GWAS2523522_H GCST90018733 Eosinophil count 93,063 East Asian ancestry individuals C 0.969523 3E-9 8.523 rs1888909 0.0762913 eosinophil count (EFO:0004842)
 PMID:34594039
GWAS2646861_H GCST90056180 Eosinophil count 234,763 European ancestry individuals T 0.256 9E-154 153.046 rs1888909 N/A eosinophil count (EFO:0004842)
 PMID:34469753
GWAS1469097_H GCST007444 Chronic rhinosinusitis 251 European ancestry whole-genome sequenced cases, 5,357 European ancestry cases, 13,957 European ancestry whole-genome sequenced controls, 746,129 European ancestry controls T 0.253 6E-7 6.222 rs1888909 1.12 chronic rhinosinusitis (EFO:1000024)
 PMID:30643255
GWAS1469101_H GCST007443 Nasal polyps 86 European ancestry whole-genome sequenced cases, 4,280 European ancestry cases, 13,941 European ancestry whole-genome sequenced controls, 700,740 European ancestry controls T 0.253 7E-32 31.155 rs1888909 1.34 Nasal Cavity Polyp (EFO:1000391)
 PMID:30643255
GWAS2723133_H GCST90468068 Eosinophill count (UKB data field 30150) 394,642 European ancestry individuals C 0.74465466 2E-250 249.699 rs1888909 0.076284416 eosinophil count (EFO:0004842)
 PMID:39789286
GWAS2800006_H GCST90134621 Eosinophil count 365,954 British ancestry individuals T 0.26 7E-125 124.155 rs1888909 0.1 eosinophil count (EFO:0004842)
 PMID:35935937
GWAS2871297_H GCST90476021 Allergic rhinitis (PheCode 476) 92,310 European ancestry cases, 311,377 European ancestry controls T 0.2744 9E-18 17.046 rs1888909 0.05207 allergic rhinitis (EFO:0005854)
 PMID:39024449
GWAS2890260_H GCST90475297 eosinophil (fraction, maximum, inv-norm transformed) 335,542 European ancestry individuals T 0.2749 7E-168 167.155 rs1888909 0.09279 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS2891567_H GCST90475300 eosinophil (fraction, mean, inv-norm transformed) 335,542 European ancestry individuals T 0.2749 3E-207 206.523 rs1888909 0.106 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS2891593_H GCST90475288 eosinophil (absolute count, maximum, inv-norm transformed) 310,588 European ancestry individuals T 0.2752 4E-143 142.398 rs1888909 0.08919 eosinophil count (EFO:0004842)
 PMID:39024449
GWAS2897200_H GCST90480249 Asthma 12,093 African American or Afro-Caribbean cases, 105,134 African American or Afro-Caribbean controls, 5,688 Hispanic or Latin American cases, 52,071 Hispanic or Latin American controls, 609 East Asian ancestry cases, 6,004 East Asian ancestry controls, 36,823 European ancestry cases, 398,278 European ancestry controls T 0.3106 5E-31 30.302 rs1888909 0.08906 PMID:39024449
GWAS2899190_H GCST90480233 Nasal polyps (PheCode 471) 905 African American or Afro-Caribbean cases, 120,199 African American or Afro-Caribbean controls, 4,037 European ancestry cases, 444,004 European ancestry controls, 452 Hispanic or Latin American cases, 59,080 Hispanic or Latin American controls T 0.3131 2E-28 27.699 rs1888909 0.2467 Nasal polyposis (HP:0100582)
 PMID:39024449
GWAS2904565_H GCST90480683 Biological Sibling: Asthma 5,022 African American or Afro-Caribbean cases, 50,483 African American or Afro-Caribbean controls, 2,302 Hispanic or Latin American cases, 27,012 Hispanic or Latin American controls, 313 East Asian ancestry cases, 3,234 East Asian ancestry controls, 18,209 European ancestry cases, 297,459 European ancestry controls T 0.2998 9E-13 12.046 rs1888909 0.07644 family history (EFO:0000493)
 PMID:39024449
Database Acc Id Source(s)
GWAS Catalog GCST90479603 GWAS Catalog

RGD Curation Notes
Note Type Note Reference