GWAS1028654_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1028654_H (esterified cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028654 (human)) Homo sapiens

Symbol: GWAS1028654_H
Name: esterified cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028654 (human)
RGD ID: 407379678
Trait: esterified cholesterol measurement, low density lipoprotein cholesterol measurement
Measurement Type: blood low density lipoprotein cholesterol level   (CMO:0000053)    
LOD Score: Not Available
P Value: 6.0E-14
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh381911,079,858 - 11,079,859RGD_MAPPER_PIPELINEGRCh38
GRCh371911,190,534 - 11,190,535RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1028654_HHumanblood low density lipoprotein cholesterol level  IAGPrs142158911405850206Based on the EFO term IDGWAS_CATALOGPMID:34610981

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS1028654_HHumanesterified cholesterol measurement  IAGPrs142158911405850206 GWAS_CATALOGPMID:34610981
GWAS1028654_HHumanlow density lipoprotein cholesterol measurement  IAGPrs142158911405850206 GWAS_CATALOGPMID:34610981
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs142158911)
Human AssemblyChrPosition (strand)Source
GRCh381911,079,858 - 11,079,859RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407375690GWAS1024666_Hlow density lipoprotein cholesterol measurement, lipid measurement QTL GWAS1024666 (human)3e-12low density lipoprotein cholesterol measurement, lipid measurementblood lipid measurement (CMO:0000050)191107985811079859Human
407076160GWAS725136_Hphospholipids:total lipids ratio QTL GWAS725136 (human)3e-62phospholipids:total lipids ratio191107985811079859Human
407375692GWAS1024668_Hlow density lipoprotein cholesterol measurement QTL GWAS1024668 (human)5e-12low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
407030984GWAS679960_Hphospholipids in very small VLDL measurement QTL GWAS679960 (human)1e-76phospholipids in very small VLDL measurement 191107985811079859Human
407417730GWAS1066706_Htriglyceride measurement, high density lipoprotein cholesterol measurement QTL GWAS1066706 (human)2e-15triglyceride measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)191107985811079859Human
407375684GWAS1024660_Htotal cholesterol measurement QTL GWAS1024660 (human)1e-10total cholesterol measurementblood total cholesterol level (CMO:0000051)191107985811079859Human
407401733GWAS1050709_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1050709 (human)2e-08Agents acting on the renin-angiotensin system use measurement191107985811079859Human
407029772GWAS678748_Hlinoleic acid measurement QTL GWAS678748 (human)7e-38linoleic acid measurementblood free fatty acids level (CMO:0000117)191107985811079859Human
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
407379036GWAS1028012_Hesterified cholesterol measurement QTL GWAS1028012 (human)4e-10esterified cholesterol measurement191107985811079859Human
407379676GWAS1028652_Hlow density lipoprotein cholesterol measurement QTL GWAS1028652 (human)1e-13omega-3 polyunsaturated fatty acid measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407371869GWAS1020845_Hvitamin D measurement QTL GWAS1020845 (human)4e-16vitamin D measurement191107985811079859Human
407414686GWAS1063662_Htotal cholesterol measurement QTL GWAS1063662 (human)2e-428total cholesterol measurementblood total cholesterol level (CMO:0000051)191107985811079859Human
407379678GWAS1028654_Hesterified cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028654 (human)6e-14esterified cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407411792GWAS1060768_Hlinoleic acid measurement QTL GWAS1060768 (human)3e-47linoleic acid measurementblood free fatty acids level (CMO:0000117)191107985811079859Human
407039646GWAS688622_Hsaturated fatty acids measurement QTL GWAS688622 (human)1e-18choline measurement191107985811079859Human
407411796GWAS1060772_Homega-6 polyunsaturated fatty acid measurement QTL GWAS1060772 (human)2e-50omega-6 polyunsaturated fatty acid measurement191107985811079859Human
407371862GWAS1020838_Hvitamin D measurement QTL GWAS1020838 (human)3e-17vitamin D measurement191107985811079859Human
407416919GWAS1065895_Hphospholipid measurement QTL GWAS1065895 (human)8e-17phospholipid measurement191107985811079859Human
407380009GWAS1028985_Hfree cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028985 (human)2e-11free cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
407030113GWAS679089_Hfatty acid measurement QTL GWAS679089 (human)4e-24fatty acid measurement191107985811079859Human
407033830GWAS682806_Htotal lipids in very small VLDL measurement QTL GWAS682806 (human)2e-79total lipids in very small VLDL measurement191107985811079859Human
407040741GWAS689717_Hpolyunsaturated fatty acid measurement QTL GWAS689717 (human)2e-37milk polyunsaturated fatty acid amount (VT:0010374)milk polyunsaturated fatty acid measurement (CMO:0000821)191107985811079859Human
407379680GWAS1028656_Hlow density lipoprotein cholesterol measurement, phospholipid measurement QTL GWAS1028656 (human)3e-11low density lipoprotein cholesterol measurement, phospholipid measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407379681GWAS1028657_Hfree cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028657 (human)8e-13free cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407379042GWAS1028018_Htotal cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028018 (human)2e-13total cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407380004GWAS1028980_Hlow density lipoprotein cholesterol measurement QTL GWAS1028980 (human)3e-13low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407379684GWAS1028660_Hlow density lipoprotein cholesterol measurement, lipid measurement QTL GWAS1028660 (human)4e-13low density lipoprotein cholesterol measurementblood lipid measurement (CMO:0000050)191107985811079859Human
407052142GWAS701118_Hparental longevity QTL GWAS701118 (human)8e-09parental longevity191107985811079859Human
407380005GWAS1028981_Hesterified cholesterol measurement, low density lipoprotein cholesterol measurement QTL GWAS1028981 (human)9e-14esterified cholesterol measurement, low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
407040492GWAS689468_Htotal lipids in lipoprotein particles measurement QTL GWAS689468 (human)9e-55total lipids in lipoprotein particles measurement 191107985811079859Human
407108784GWAS757760_Htotal phospholipids in lipoprotein particles measurement QTL GWAS757760 (human)4e-34total phospholipids in lipoprotein particles measurement 191107985811079859Human
407042038GWAS691014_Hphosphatidylcholine measurement QTL GWAS691014 (human)5e-13phosphatidylcholine measurement191107985811079859Human
407414193GWAS1063169_HAntithrombotic agent use measurement QTL GWAS1063169 (human)8e-18Antithrombotic agent use measurement191107985811079859Human
407202111GWAS851087_Haging QTL GWAS851087 (human)1e-09low density lipoprotein cholesterol measurement, phospholipid measurementblood low density lipoprotein cholesterol level (CMO:0000053)191107985811079859Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
407029502GWAS678478_Homega-6 polyunsaturated fatty acid measurement QTL GWAS678478 (human)3e-40omega-6 polyunsaturated fatty acid measurement191107985811079859Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS678478_H GCST90269542 Omega-6 fatty acids levels (UKB data field 23445) 88,268 European ancestry individuals A 0.115791 3E-40 39.523 rs142158911 0.0962468 omega-6 polyunsaturated fatty acid measurement (EFO:0005680)
 PMID:36764567
GWAS678748_H GCST90269546 Linoleic acid levels (UKB data field 23449) 88,268 European ancestry individuals A 0.115791 7E-38 37.155 rs142158911 0.0934941 linoleic acid measurement (EFO:0006807)
 PMID:36764567
GWAS679089_H GCST90269539 Total fatty acids levels (UKB data field 23442) 88,268 European ancestry individuals A 0.115791 4E-24 23.398 rs142158911 0.0743171 fatty acid measurement (EFO:0005110)
 PMID:36764567
GWAS679960_H GCST90269615 Phospholipids in very small VLDL (UKB data field 23518) 88,329 European ancestry individuals A 0.115816 1E-76 76 rs142158911 0.135201 phospholipids in very small VLDL measurement (EFO:0022300)
 PMID:36764567
GWAS682806_H GCST90269614 Total lipids in very small VLDL (UKB data field 23517) 88,329 European ancestry individuals A 0.115816 2E-79 78.699 rs142158911 0.137358 total lipids in very small VLDL measurement (EFO:0022156)
 PMID:36764567
GWAS688622_H GCST90269545 Saturated fatty acids levels (UKB data field 23448) 88,268 European ancestry individuals A 0.115791 1E-18 18 rs142158911 0.0646718 saturated fatty acids measurement (EFO:0022304)
 PMID:36764567
None Available GCST90269533 Total cholines levels (UKB data field 23436) 88,268 European ancestry individuals A 0.115791 1E-18 18 rs142158911 0.0614056 choline measurement (EFO:0010116)
 PMID:36764567
GWAS689468_H GCST90269520 Total lipids in lipoprotein particles (UKB data field 23423) 88,329 European ancestry individuals A 0.115816 9E-55 54.046 rs142158911 0.113739 total lipids in lipoprotein particles measurement (EFO:0022309)
 PMID:36764567
GWAS689717_H GCST90269543 Polyunsaturated fatty acids levels (UKB data field 23446) 88,268 European ancestry individuals A 0.115791 2E-37 36.699 rs142158911 0.0924983 polyunsaturated fatty acid measurement (EFO:0010733)
 PMID:36764567
GWAS691014_H GCST90269534 Phosphatidylcholines levels (UKB data field 23437) 88,268 European ancestry individuals A 0.115791 5E-13 12.302 rs142158911 0.0501915 phosphatidylcholine measurement (EFO:0010226)
 PMID:36764567
GWAS701118_H GCST009890 Parental lifespan at least 500,193 European ancestry offspring A 0.12 8E-9 8.097 rs142158911 0.355 parental longevity (EFO:0007796)
 PMID:30642433
GWAS725136_H GCST90269681 Phospholipids to total lipids in very large VLDL percentage (UKB data field 23584) 87,620 European ancestry individuals A 0.115749 3E-62 61.523 rs142158911 0.12338 phospholipids:total lipids ratio (EFO:0020946)
 PMID:36764567
GWAS757760_H GCST90269508 Total phospholipids in lipoprotein particles (UKB data field 23411) 88,329 European ancestry individuals A 0.115816 4E-34 33.398 rs142158911 0.0860905 total phospholipids in lipoprotein particles measurement (EFO:0022315)
 PMID:36764567
GWAS851087_H GCST90321079 Aging 1,559,001 European ancestry individuals G NR 1E-9 9 rs142158911 0.010108087 aging (EFO:0022597)
 PMID:37550455
GWAS1020838_H GCST90000616 Serum 25-Hydroxyvitamin D levels 417,580 European ancestry individuals G 0.885392 3E-17 16.523 rs142158911 0.026 vitamin D measurement (EFO:0004631)
 PMID:32242144
GWAS1020845_H GCST90000618 Serum 25-Hydroxyvitamin D levels 496,946 European ancestry individuals ? NR 4E-16 15.398 rs142158911 0.026284 vitamin D measurement (EFO:0004631)
 PMID:32242144
GWAS1050709_H GCST007930 Medication use (agents acting on the renin-angiotensin system) 62,752 European ancestry cases, 174,778 European ancestry controls A 0.114529 2E-8 7.699 rs142158911 0.05320513 Agents acting on the renin-angiotensin system use measurement (EFO:0009931)
 PMID:31015401
None Available GCST90092931 Omega-3 fatty acid levels 115,006 European ancestry individuals G 0.883297 1E-13 13 rs142158911 0.0461641 omega-3 polyunsaturated fatty acid measurement (EFO:0010119)
 PMID:35213538
None Available GCST90091600 Fasting total lipids in small LDL null A 0.119194883 3E-12 11.523 rs142158911 0.222513 low density lipoprotein cholesterol measurement (EFO:0004611)
lipid measurement (EFO:0004529)
 PMID:34610981
None Available GCST90091601 Fasting small LDL particle concentration null A 0.119194883 5E-12 11.302 rs142158911 0.220647 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091602 Fasting phospholipid levels in small LDL null A 0.119194883 1E-9 9 rs142158911 0.194293 low density lipoprotein cholesterol measurement (EFO:0004611)
phospholipid measurement (EFO:0004639)
 PMID:34610981
GWAS1060768_H GCST90133363 Linoleic acid levels 114,999 European ancestry individuals G 0.88 3E-47 46.523 rs142158911 0.092 linoleic acid measurement (EFO:0006807)
 PMID:35692035
GWAS1060772_H GCST90133364 Total omega-6 fatty acid levels 114,999 European ancestry individuals G 0.88 2E-50 49.699 rs142158911 0.094 omega-6 polyunsaturated fatty acid measurement (EFO:0005680)
 PMID:35692035
None Available GCST90091587 Fasting serum total cholesterol null A 0.119174609 1E-10 10 rs142158911 0.205258 total cholesterol measurement (EFO:0004574)
 PMID:34610981
None Available GCST90091570 Fasting free cholesterol in medium LDL null A 0.11925018 8E-13 12.097 rs142158911 0.228081 free cholesterol measurement (EFO:0008591)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091512 Fasting esterified cholesterol null A 0.119322646 4E-10 9.398 rs142158911 0.199418 esterified cholesterol measurement (EFO:0008589)
 PMID:34610981
None Available GCST90091536 Fasting total cholesterol in LDL null A 0.119174609 2E-13 12.699 rs142158911 0.2354 total cholesterol measurement (EFO:0004574)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091597 Fasting total cholesterol in small LDL null A 0.119194883 3E-13 12.523 rs142158911 0.233199 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091598 Fasting cholesterol esters in small LDL null A 0.119194883 9E-14 13.046 rs142158911 0.237468 esterified cholesterol measurement (EFO:0008589)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091599 Fasting free cholesterol in small LDL null A 0.119194883 2E-11 10.699 rs142158911 0.213436 free cholesterol measurement (EFO:0008591)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091568 Fasting total cholesterol in medium LDL null A 0.11925018 1E-13 13 rs142158911 0.237245 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091569 Fasting cholesterol esters in medium LDL null A 0.11925018 6E-14 13.222 rs142158911 0.239019 esterified cholesterol measurement (EFO:0008589)
low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091571 Fasting total lipids in medium LDL null A 0.11925018 4E-13 12.398 rs142158911 0.231715 low density lipoprotein cholesterol measurement (EFO:0004611)
lipid measurement (EFO:0004529)
 PMID:34610981
None Available GCST90091572 Fasting medium LDL particle concentration null A 0.11925018 4E-13 12.398 rs142158911 0.230866 low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34610981
None Available GCST90091573 Fasting phospholipid levels in medium LDL null A 0.11925018 3E-11 10.523 rs142158911 0.212734 low density lipoprotein cholesterol measurement (EFO:0004611)
phospholipid measurement (EFO:0004639)
 PMID:34610981
None Available GCST90448682 25-hydroxyvitamin D levels (skin colour stratified) 409,654 European ancestry individuals G 0.89 6E-15 14.222 rs142158911 0.025 vitamin D measurement (EFO:0004631)
 PMID:37963177
GWAS1063169_H GCST90018982 Medication use (antithrombotic agents) 67,653 European ancestry cases, 85,986 European ancestry controls, 54,220 East Asian ancestry cases, 124,506 East Asian ancestry controls A NR 8E-18 17.097 rs142158911 0.0919 Antithrombotic agent use measurement (EFO:0009925)
 PMID:34594039
GWAS1063662_H GCST90018974 Total cholesterol levels 344,278 European ancestry individuals, 135,808 East Asian ancestry individuals A NR 2E-428 427.699 rs142158911 0.1611 total cholesterol measurement (EFO:0004574)
 PMID:34594039
GWAS1065895_H GCST90092938 Phosphoglycerides levels 115,006 European ancestry individuals G 0.883297 8E-17 16.097 rs142158911 0.0508755 phospholipid measurement (EFO:0004639)
 PMID:35213538
None Available GCST90092937 Phosphatidylcholine levels 115,006 European ancestry individuals G 0.883297 8E-17 16.097 rs142158911 0.0503532 phospholipid measurement (EFO:0004639)
 PMID:35213538
GWAS1066706_H GCST90093014 Triglyceride levels in very large HDL 115,082 European ancestry individuals G 0.883281 2E-15 14.699 rs142158911 0.0501444 triglyceride measurement (EFO:0004530)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:35213538
Database Acc Id Source(s)
GWAS Catalog GCST90091569 GWAS Catalog

RGD Curation Notes
Note Type Note Reference