GWAS898963_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS898963_H (major depressive disorder QTL GWAS898963 (human)) Homo sapiens

Symbol: GWAS898963_H
Name: major depressive disorder QTL GWAS898963 (human)
RGD ID: 407249987
Trait: major depressive disorder
LOD Score: Not Available
P Value: 6.0E-16
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3818,420,956 - 8,420,957RGD_MAPPER_PIPELINEGRCh38
GRCh3718,481,016 - 8,481,017RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS898963_HHumanmajor depressive disorder  IAGPrs301805405850206 GWAS_CATALOGPMID:38177345
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1344336REREarginine-glutamic acid dipeptide repeats183524048817640Human

Position Markers

Peak: (rs301805)
Human AssemblyChrPosition (strand)Source
GRCh3818,420,956 - 8,420,957RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
406961795GWAS610771_Hpain QTL GWAS610771 (human)2e-08pain184209568420957Human
407047360GWAS696336_Hneuroticism measurement, cognitive function measurement QTL GWAS696336 (human)3e-15neuroticism measurement, cognitive function measurement184209568420957Human
407249987GWAS898963_Hmajor depressive disorder QTL GWAS898963 (human)6e-16major depressive disorder184209568420957Human
407010180GWAS659156_Hsmoking initiation QTL GWAS659156 (human)3e-09smoking initiation184209568420957Human
407134253GWAS783229_Hasthma, allergic disease QTL GWAS783229 (human)6e-09asthma, allergic disease184209568420957Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human
406920460GWAS569436_Hsmoking behavior QTL GWAS569436 (human)4e-08smoking behavior184209568420957Human
407121241GWAS770217_Hsmoking status measurement QTL GWAS770217 (human)8e-09smoking status measurement184209568420957Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS569436_H GCST007327 Smoking status (ever vs never smokers) 518,633 European ancestry individuals T 0.4227 4E-8 7.398 rs301805 0.011173298 smoking behavior (EFO:0004318)
 PMID:30643258
GWAS610771_H GCST90104572 Pain (pleiotropy) 361,194 European ancestry individuals ? NR 2E-8 7.699 rs301805 0.014 pain (EFO:0003843)
 PMID:37844115
GWAS659156_H GCST011703 Smoking initiation 842,717 European ancestry individuals T NR 3E-9 8.523 rs301805 0.979 smoking initiation (EFO:0005670)
 PMID:33082346
GWAS696336_H GCST90270074 Personality traits or cognitive traits (multivariate analysis) 337,125 British ancestry individuals ? NR 3E-15 14.523 rs301805 N/A neuroticism measurement (EFO:0007660)
cognitive function measurement (EFO:0008354)
 PMID:37365406
GWAS770217_H GCST007085 Smoking status approximately 458,000 European ancestry individuals ? NR 8E-9 8.097 rs301805 N/A smoking status measurement (EFO:0006527)
 PMID:30595370
GWAS783229_H GCST007564 Asthma or allergic disease (pleiotropy) 14,085 European asthma cases, 25,685 European ancestry allergic diseases cases, 76,768 European ancestry controls ? NR 6E-9 8.222 rs301805 1.0416667 PMID:29785011
GWAS898963_H GCST90328131 Major depressive disorder (broad) 258,364 European ancestry cases, 571,252 European ancestry controls, 36,818 African ancestry cases, 161,679 African ancestry controls, 21,980 East Asian ancestry cases, 360,956 East Asian ancestry controls, 4,505 South Asian ancestry cases, 27,176 South Asian ancestry controls, 25,013 Hispanic or Latin American cases, 352,946 Hispanic or Latin American controls T 0.4033 6E-16 15.222 rs301805 0.0253 PMID:38177345
None Available GCST90435414 Diastolic blood pressure 404,337 European ancestry individuals ? NR 2E-12 11.699 rs301805 0.0148122 diastolic blood pressure (EFO:0006336)
 PMID:39134668
None Available GCST90435415 Systolic blood pressure 404,507 European ancestry individuals ? NR 2E-10 9.699 rs301805 0.01247 systolic blood pressure (EFO:0006335)
 PMID:39134668
Database Acc Id Source(s)
GWAS Catalog GCST90328131 GWAS Catalog

RGD Curation Notes
Note Type Note Reference