GWAS841705_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS841705_H (alkaline phosphatase measurement QTL GWAS841705 (human)) Homo sapiens

Symbol: GWAS841705_H
Name: alkaline phosphatase measurement QTL GWAS841705 (human)
RGD ID: 407192729
Trait: alkaline phosphatase measurement
Measurement Type: blood alkaline phosphatase activity level   (CMO:0000576)    
LOD Score: Not Available
P Value: 1E-1311
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38121,563,267 - 21,563,268RGD_MAPPER_PIPELINEGRCh38
GRCh37121,889,760 - 21,889,761RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS841705_HHumanblood alkaline phosphatase activity level  IAGPrs149344982405850206Based on the EFO term IDGWAS_CATALOGPMID:33462484

Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS841705_HHumanalkaline phosphatase measurement  IAGPrs149344982405850206 GWAS_CATALOGPMID:33462484
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1346147ALPLalkaline phosphatase, biomineralization associated12150898421578410Human

Position Markers

Peak: (rs149344982)
Human AssemblyChrPosition (strand)Source
GRCh38121,563,267 - 21,563,268RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
407314342GWAS963318_Hblood phosphate measurement QTL GWAS963318 (human)7e-19blood phosphate amount (VT:0001565)blood phosphate level (CMO:0000504)12156326721563268Human
407284389GWAS933365_Halkaline phosphatase measurement QTL GWAS933365 (human)6e-1229alkaline phosphatase measurementblood alkaline phosphatase activity level (CMO:0000576)12156326721563268Human
406936421GWAS585397_Halkaline phosphatase measurement QTL GWAS585397 (human)1e-157alkaline phosphatase measurementblood alkaline phosphatase activity level (CMO:0000576)12156326721563268Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
407192729GWAS841705_Halkaline phosphatase measurement QTL GWAS841705 (human)1e-1311alkaline phosphatase measurementblood alkaline phosphatase activity level (CMO:0000576)12156326721563268Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS585397_H GCST009652 Serum alkaline phosphatase levels 162,774 Icelandic ancestry individuals A 0.015 1E-157 157 rs149344982 0.46 alkaline phosphatase measurement (EFO:0004533)
 PMID:31666285
GWAS841705_H GCST90019494 Serum alkaline phosphatase levels 342,535 European ancestry individuals, 6,019 African ancestry individuals, 7,337 South Asian ancestry individuals A NR 1E-1311 1311 rs149344982 0.7848 alkaline phosphatase measurement (EFO:0004533)
 PMID:33462484
GWAS933365_H GCST90018942 Serum alkaline phosphatase levels 344,292 European ancestry individuals, 118,886 East Asian ancestry individuals A NR 6E-1229 1228.222 rs149344982 0.751 alkaline phosphatase measurement (EFO:0004533)
 PMID:34594039
GWAS963318_H GCST90019516 Serum phosphate levels 312,888 European ancestry individuals, 5,568 African ancestry individuals, 6,685 South Asian ancestry individuals A NR 7E-19 18.155 rs149344982 0.0947 blood phosphate measurement (EFO:0010972)
 PMID:33462484
None Available GCST90448598 Alkaline phosphatase levels 38,000 South Asian ancestry individuals A NR 1E-184 184 rs149344982 0.657 alkaline phosphatase measurement (EFO:0004533)
 PMID:39414775
Database Acc Id Source(s)
GWAS Catalog GCST90019494 GWAS Catalog

RGD Curation Notes
Note Type Note Reference