GWAS737926_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS737926_H (total cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS737926 (human)) Homo sapiens

Symbol: GWAS737926_H
Name: total cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS737926 (human)
RGD ID: 407088950
Trait: total cholesterol change measurement, high density lipoprotein cholesterol measurement
Measurement Type: blood high density lipoprotein cholesterol level   (CMO:0000052)    
blood total cholesterol level   (CMO:0000051)    
LOD Score: Not Available
P Value: 3.0E-10
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3871,180,020 - 1,180,021RGD_MAPPER_PIPELINEGRCh38
GRCh3771,219,656 - 1,219,657RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Data Annotations    Click to see Annotation Detail View

Clinical Measurement
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS737926_HHumanblood high density lipoprotein cholesterol level  IAGPrs10277990405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586
GWAS737926_HHumanblood total cholesterol level  IAGPrs10277990405850206Based on the EFO term IDGWAS_CATALOGPMID:38448586

Experimental Factor Annotations    Click to see Annotation Detail View
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Position Markers

Peak: (rs10277990)
Human AssemblyChrPosition (strand)Source
GRCh3871,180,020 - 1,180,021RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407086963GWAS735939_Htotal lipids in large HDL QTL GWAS735939 (human)1e-11total lipids in large HDL711800201180021Human
1643402BMD2_HBone mineral density QTL 2 (human)2.690.0002Bone mineral density7122435431Human
407088950GWAS737926_Htotal cholesterol change measurement, high density lipoprotein cholesterol measurement QTL GWAS737926 (human)3e-10cholesterol esters in large HDL measurementblood high density lipoprotein cholesterol level (CMO:0000052)711800201180021Human
1643247BW130_HBody Weight QTL 130 (human)1.280.008Body weightbody mass index7117453493Human
1643391BW322_HBody weight QTL 322 (human)2.690.0002Body fat amount7122435431Human
407042107GWAS691083_Halcohol consumption measurement QTL GWAS691083 (human)2e-11triglycerides in very large HDL measurement blood high density lipoprotein phospholipid level (CMO:0001565)711800201180021Human
407330590GWAS979566_Halcohol consumption measurement QTL GWAS979566 (human)5e-12alcohol consumption measurementethanol drink intake rate (CMO:0001407)711800201180021Human
407079389GWAS728365_Hhigh density lipoprotein cholesterol measurement QTL GWAS728365 (human)6e-12high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)711800201180021Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS691083_H GCST90243989 Drinks per week 2,965,643 European ancestry, East Asian ancestry, Hispanic or Latin American, African ancestry individuals C 0.385 2E-11 10.699 rs10277990 0.00569 alcohol consumption measurement (EFO:0007878)
 PMID:36477530
GWAS728365_H GCST90302002 Concentration of large HDL particles 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.6089 6E-12 11.222 rs10277990 0.0298 high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90302003 Phospholipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.6088 2E-11 10.699 rs10277990 0.0291 phospholipids in large HDL measurement (EFO:0022190)
 PMID:38448586
GWAS735939_H GCST90302001 Total lipids in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.6089 1E-11 11 rs10277990 0.0294 total lipids in large HDL (EFO:0022189)
 PMID:38448586
GWAS737926_H GCST90301995 Total cholesterol in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.6089 3E-10 9.523 rs10277990 0.0274 total cholesterol change measurement (EFO:0007806)
high density lipoprotein cholesterol measurement (EFO:0004612)
 PMID:38448586
None Available GCST90301997 Cholesterol esters in large HDL 4,435 East Asian ancestry individuals, 11,340 South Asian ancestry individuals, 120,241 European ancestry individuals A 0.6089 3E-10 9.523 rs10277990 0.0273 cholesterol esters in large HDL measurement (EFO:0022159)
 PMID:38448586
None Available GCST90269654 Triglycerides in very large HDL (UKB data field 23557) 88,329 European ancestry individuals C 0.381904 2E-11 10.699 rs10277990 0.0329959 triglycerides in very large HDL measurement (EFO:0022324)
 PMID:36764567
GWAS979566_H GCST90243984 Drinks per week 2,428,851 European ancestry individuals C 0.385 5E-12 11.302 rs10277990 0.00643 alcohol consumption measurement (EFO:0007878)
 PMID:36477530
Database Acc Id Source(s)
GWAS Catalog GCST90301995 GWAS Catalog
  GCST90301997 GWAS Catalog

RGD Curation Notes
Note Type Note Reference