Bp344 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp344 (Blood pressure QTL 344) Rattus norvegicus

Symbol: Bp344
Name: Blood pressure QTL 344
RGD ID: 2316649
Previously known as: BP QTL region 2; BP QTL2
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2132,249,735 - 33,038,814RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0134,888,392 - 35,680,732RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0136,290,530 - 37,078,065RGDRnor5.0
RGSC_v3.4172,374,083 - 3,178,843RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: SS.LEW-(D1Mco102-D1Mco129)/1Mco SS.LEW-(D1Mco102-D1Mco129)/2Mco 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Candidate Gene Status
Ice1 is a candidate Gene for Bp344
Adamts16 is a candidate Gene for Bp344

Disease Annotations     Click to see Annotation Detail View
Hypotension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Positional identification of variants of Adamts16 linked to inherited hypertension. Joe B, etal., Hum Mol Genet. 2009 Aug 1;18(15):2825-38. Epub 2009 May 7.
2. Multiple blood pressure loci with opposing blood pressure effects on rat chromosome 1 in a homologous region linked to hypertension on human chromosome 15. Mell B, etal., Hypertens Res. 2015 Jan;38(1):61-7. doi: 10.1038/hr.2014.134. Epub 2014 Sep 18.
Related QTLs

Related QTL Description Reference
BP47_H maps to syntenic region RGD:2312639
Bp153 sub_region RGD:2312639


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1309747Ice1interactor of little elongation complex ELL subunit 113264037232682669Rat
1310046Adamts16ADAM metallopeptidase with thrombospondin type 1 motif, 1613243043632562481Rat
11364129LOC10834973040S ribosomal protein S20 pseudogene13275477832761865Rat
41053469LOC120097702uncharacterized LOC12009770213260885332613035Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
37598D1Rat17618913273727332737458Ratregion
36640D1Rat1416613235591032356093Ratregion
42456D1Rat33017213297220532972379Ratregion
42456D1Rat33017213297220532972816Ratregion
42456D1Rat33017213297229132972379Ratregion
1626786D1Mco7525013276550232766175Ratregion
1626786D1Mco7525013276592532766175Ratregion
1627856D17Got21514913248534932485498Ratregion
1638813D1Got30517313230874832308921Ratregion
2315138D1Mco12224813294179832942046Ratregion
2315140D1Mco12321913298979032990009Ratregion
2315142D1Mco10919613247778632477938Ratregion
2315142D1Mco10919613247778632477982Ratregion
2315144D1Mco11519313271591432716107Ratregion
2315146D1Mco12020613291597532916181Ratregion
2315148D1Mco11215013256248432562634Ratregion
2315150D1Mco10417913228523332285412Ratregion
2315152D1Mco11016613250438532504551Ratregion
2315154D1Mco12117313294091832941007Ratregion
2315154D1Mco12117313294091832941091Ratregion
2315156D1Mco11316713260079432600959Ratregion
2315158D1Mco12419113298981832990009Ratregion
2315160D1Mco12916413303865033038814Ratregion
2315162D1Mco10218413224973532249921Ratregion
2315164D1Mco11415713267188732672062Ratregion
2315166D1Mco12617113301522333015396Ratregion
2315168D1Mco12715113301728333017434Ratregion
2315170D1Mco10818613244265532442841Ratregion
2315178D1Mco12518913299308932993282Ratregion
2315180D1Mco11615713276659832766755Ratregion
2315182D1Mco11816713282541632825585Ratregion
2315184D1Mco10616013242914032429288Ratregion
2315186D1Mco10518813233341032333598Ratregion
2315188D1Mco12816813301730433017472Ratregion
2315190D1Mco11724113278412632784318Ratregion
2315192D1Mco10315113227305632273209Ratregion
2315194D1Mco10716013243322532433375Ratregion
Position Markers

Flank 1: (D1Mco102)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2132,249,735 - 32,249,921 (+)MAPPER
Rnor_6.0134,888,392 - 34,888,575NCBI
Rnor_5.0136,290,530 - 36,290,713UniSTS
RGSC_v3.4172,374,083 - 2,374,266UniSTS
Celera130,876,304 - 30,876,487UniSTS
Cytogenetic Map1 RGD
Flank 2: (D1Mco129)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2133,038,650 - 33,038,814 (+)MAPPER
Rnor_6.0135,680,569 - 35,680,732NCBI
Rnor_5.0137,077,902 - 37,078,065UniSTS
RGSC_v3.4173,178,680 - 3,178,843UniSTS
Celera131,653,745 - 31,653,908UniSTS
Cytogenetic Map1 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
731169Bp153Blood pressure QTL 1530.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13105084033492143Rat
2316649Bp344Blood pressure QTL 344arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13224973533038814Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_gene Adamts16 is prominently expressed in the kidney 2312639
qtl_general This region spans 804.6 kb 2312639
qtl_general number of animals used: 20 males from each set 2312639
qtl_general measurement method: animals were weaned at 30 days of age and given 0.4% NaCl diet; at 40-42 days of age 2% NaCl diet was given for 24 days and systolic bolld pressure was measured 2312639