GLUCO133_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GLUCO133_H (Glucose level QTL 133 (human)) Homo sapiens

Symbol: GLUCO133_H
Name: Glucose level QTL 133 (human)
RGD ID: 2315058
Trait: Glucose level
LOD Score: 4.295
P Value: 0.02
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,682,467 - 161,192,914RGDGRCh37
Build 361157,949,091 - 159,459,538RGDNCBI36
Cross Type: Not Available
Population Stats: Utah families of Northern European ancestry



Candidate Gene Status
APOA2 is a candidate Gene for GLUCO133_H
PKLR is a candidate Gene for GLUCO133_H
LMX1A is a candidate Gene for GLUCO133_H

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Elbein SC, etal., Diabetes. 1999 May;48(5):1175-82.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D1S2384)
Human AssemblyChrPosition (strand)Source
GRCh371159,682,467 - 159,682,815UniSTS
Build 361157,949,091 - 157,949,439RGD
Celera1132,750,913 - 132,751,261RGD
Cytogenetic Map1q23.2UniSTS
HuRef1131,038,927 - 131,039,275UniSTS
Whitehead-YAC Contig Map1 UniSTS
Flank 2: (APOA2)
Human AssemblyChrPosition (strand)Source
GRCh371161,192,773 - 161,192,914UniSTS
GRCh371161,192,279 - 161,192,840UniSTS
Build 361159,459,397 - 159,459,538RGD
Celera1134,259,434 - 134,259,995UniSTS
Celera1134,259,928 - 134,260,057RGD
Cytogenetic Map1q23.3UniSTS
HuRef1132,549,226 - 132,549,787UniSTS
HuRef1132,549,720 - 132,549,849UniSTS
Marshfield Genetic Map1170.84UniSTS
TNG Radiation Hybrid Map173258.0UniSTS
Stanford-G3 RH Map16182.0UniSTS
GeneMap99-G3 RH Map16138.0UniSTS


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general Attempt to replicate in a separate 20 family population or the combined 62 family population failed 2315040
qtl_map Chromosome 1q21-23 2315040
qtl_population Utah families of Northern European ancestry 2315040
qtl_population_details 42 families ascertained for a type 2 diabetic sib pair, 618 individuals, 526 nonfounders, age specific WHO criteria, including impaired glucose tolerance as affected, those with evidence of type 1 diabetes assigned unknown affection status 2315040
qtl_statistics_details Software used: GENEHUNTER, recessive model multipoint, parametric linkage analysis, diagnosed as diabetic or glucose intolerant as the trait, empirically determined genome-wide significance 2315040