BW187_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: BW187_H (Body weight QTL 187 (human)) Homo sapiens

Symbol: BW187_H
Name: Body weight QTL 187 (human)
RGD ID: 1643095
Trait: Body fat amount
Measurement Type: percent body fat
LOD Score: 2.04
P Value: 0.001085
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372042,514,283 - 63,025,520RGD_MAPPER_PIPELINEGRCh37
Build 362041,947,690 - 62,435,964RGDNCBI36
Cross Type: Not Available
Population Stats: Caucasian and African American families ascertained through morbidly obese probands



Candidate Gene Status
ASIP is a candidate Gene for BW187_H
GNAS is a candidate Gene for BW187_H
CEBPB is a candidate Gene for BW187_H
HNF4A is a candidate Gene for BW187_H
MC3R is a candidate Gene for BW187_H
PCK1 is a candidate Gene for BW187_H

Disease Annotations     Click to see Annotation Detail View
obesity  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genome scan for human obesity and linkage to markers in 20q13. Lee JH, etal., Am J Hum Genet. 1999 Jan;64(1):196-209.

Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Peak: (D20S149)
Human AssemblyChrPosition (strand)Source
GRCh372055,514,140 - 55,514,427UniSTS
Build 362054,947,547 - 54,947,834RGD
Celera2052,254,483 - 52,254,770RGD
HuRef2052,295,947 - 52,296,242UniSTS
Marshfield Genetic Map2086.98UniSTS
Marshfield Genetic Map2086.98RGD
TNG Radiation Hybrid Map2025667.0UniSTS
Stanford-G3 RH Map202728.0UniSTS
NCBI RH Map20572.7UniSTS


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general Study Method: detailed mapping of chromosome 20q 1642891
qtl_population Caucasian and African American families ascertained through morbidly obese probands 1642891
qtl_population_details 713 individuals from 124 nuclear families chosen on the basis of one member with BMI>=40; families include additional obese siblings (BMI>=30) and normal-weight sibs and parents (BMI<27) 1642891
qtl_statistics_details Software packages: single- and multi-point analyses using the EM algorithm-based Haseman-Elston regression (EMHE) implemented by MAPMAKER/SIBS v2.0 and nonparametric-linkage (NPL) implemented by GENEHUNTER v1.1; Also, an affecteds-only model using the FASTLINK version of MLINK and an affected-sibling-pair (ASP) analysis using SIBPAIR; additional analysis using only Cacasian individuals 1642891
qtl_statistics_details LOD score 1.89 - 2.04 and p value 0.001085 - 0.0075 depending on analysis method 1642891